Human DEFB4A / BD-2

Rabbit

Human, Mouse, Rat (tested or 100% immunogen sequence identity)

Polyclonal

Unconjugated

Unmodified

Mixture of synthetic peptides (14 AA near N-Terminus of mature HBD-2, 14 AA near N-Terminus of mature rat ß-Defensin-2, and 17 AA near N-Terminus of mature mouse ß-Defensin-2) coupled to KLH for immunisation of rabbits

• ELISA (0.5 - 1 µg/ml)
• Radioimmunoassay

Human defensins are Cys-rich antimicrobial peptides which specifically react against Gram-negative bacteria. Originally defensins were isolated from hemolysates, but they can also be found on the cell surface of epithelia of the urogenital tract, lung, and trachea. In leukocytes defensins are stored in granules being released into phagolysosomes for the destruction of incorporated microorganisms. Amino acid sequences of alpha-defensins 1-4 (HNP1-4) and beta-Defensins 1-4 (HBD1-4) are known. Beta-defensin-1 and beta-defensin-2 share 34% amino acid sequence homology. ß-defensin-2 (HBD-2) whole molecule and N-terminal fragments of HBD-2, no cross-reactivity to alpha-defensin and other beta-defensins, full cross-reaction with mouse and rat beta-defensin-2.

PBS, BSA

Reconstitute with 0.1 ml distilled H2O.

Store at -20°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

NCBI: NM_004942 NP_004933.1