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Catalog Number Size Price
LS-C390858-100 100 µg (1 mg/ml) $574 
ACP5 / TRAP Antibody - Formalin-fixed, paraffin-embedded human spleen stained with TRAcP antibody (SPM601).  This image was taken for the unmodified form of this product. Other forms have not been tested.

Monoclonal Mouse anti‑Human ACP5 / TRAP Antibody (clone SPM601, Azide‑free,BSA‑free, IHC, IF) LS‑C390858

Monoclonal Mouse anti‑Human ACP5 / TRAP Antibody (clone SPM601, Azide‑free,BSA‑free, IHC, IF) LS‑C390858

Antibody:
ACP5 / TRAP Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM601) Antibody
Application:
IHC, IHC-P, IF, Flo
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Azide-free, BSA-free
Other formats:
Price
Catalog Number
$574
LS-C390858-100
Toll Free North America
(800) 227-6666
For Research Use Only

Overview

Antibody:
ACP5 / TRAP Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM601) Antibody
Application:
IHC, IHC-P, IF, Flo
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Azide-free, BSA-free
Other formats:

Specifications

Description
TRAP antibody LS-C390858 is an unconjugated mouse monoclonal antibody to TRAP (ACP5) from human. It is reactive with human, mouse and rat. Validated for Flow, IF and IHC.
Target
Human ACP5 / TRAP
Synonyms
ACP5 | SPENCDI | TrATPase | Type 5 acid phosphatase | Tartrate-resistant acid ATPase | TR-AP | TRACP5b
Host
Mouse
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG2b,k Monoclonal
Clone
SPM601
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Azide-free, BSA-free. Also available Unmodified.
Immunogen
Recombinant Full-length Human Protein.
Specificity
Human ACP5 / TRAP
Applications
  • IHC
  • IHC - Paraffin (0.5 - 1 µg/ml)
  • Immunofluorescence (0.5 - 1 µg/ml)
  • Flow Cytometry (0.5 - 1 µg/10E6 cells)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. It recognizes a protein of 35kDa, which is identified as tartrate-resistant acid phosphatase (TRAcP). It exists as two isoforms (5a and 5b). This mAb reacts with both the isoforms. Serum TRAcP 5a is secreted by macrophages and dendritic cells and increased in many patients of rheumatoid arthritis. Serum TRAcP 5b is produced from osteoclasts and elevated during bone resorption. TRAcP is an iron containing glycoprotein, which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L (+)-tartrate. TRAcP is synthesized as a latent proenzyme and is activated by proteolytic cleavage and reduction. Normally, TRAcP is highly expressed by osteoclasts, activated macrophages, neurons and endometrium during pregnancy. Expression of TRAcP is increased in certain pathological conditions such as Leukemic Reticuloendotheliosis (Hairy Cell Leukemia), Gaucher s Disease, HIV-induced Encephalopathy, Osteoclastoma and in osteoporosis and metabolic bone diseases. Anti-TRAcP antibody labels the cells of Hairy Cell Leukemia (HCL) with a high degree of sensitivity and specificity. Other cells stained with this antibody are tissue macrophages and osteoclasts. Optimal dilution of the TRAcP antibody should be determined by the researcher. Staining of formalin/paraffin tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
Presentation
1X PBS
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About ACP5 / TRAP
P13686 NM_001611 NP_001602.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 11/3/2024