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APC

Adenomatous Polyposis Coli

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Gene Name: Adenomatous Polyposis Coli
Synonyms: APC, Adenomatosis polyposis coli, Adenomatous polyposis coli, BTPS2, Deleted in polyposis 2.5, DP2, DP2.5, FPC, GS, Protein APC, PPP1R46, DP3
Target Sequences: NM_000038 NP_000029.2 P25054

Publications (2)

1
Cadherins, catenins and APC in pleural malignant mesothelioma. Abutaily AS, Collins JE, Roche WR. The Journal of pathology. 2003 201:355-62. [PubMed:14595746]
2
DNA repair genes implicated in triple negative familial non-BRCA1/2 breast cancer predisposition. Ollier M, Radosevic-Robin N, Kwiatkowski F, Ponelle F, Viala S, Privat M, Uhrhammer N, Bernard-Gallon D, Penault-Llorca F, Bignon YJ, Bidet Y. American journal of cancer research. 2015 5:2113-26. (ICC, IHC; Human) [PubMed:26328243] [PMC:PMC4548324]

☰ Filters
Antibodies (67)
ELISA Kits (16)
Proteins (6)
Cell-Based (1)
Cell-Based Phosphorylation (1)
Custom (2)
Over-Expression Lysate (2)
Primary (67)
Recombinant (4)
Sandwich (9)
Sandwich CLIA (3)
APC (89)
Human (52)
Mouse (34)
Rat (23)
Bovine (1)
Chicken (1)
Guinea pig (1)
Monkey (4)
Pig (3)
Porcine (1)
IHC (28)
IHC-Fr (1)
IHC-P (9)
WB (55)
ELISA (16)
ICC (1)
IF (8)
IP (3)
Peptide-ELISA (5)
rabbit (59)
mouse (6)
goat (1)
rat (1)
Product Group
PathPlus Cancer (1)
IgG (31)
IgG1 (5)
IgG1,k (1)
IgG2a (1)
monoclonal mc (7)
polyclonal pc (60)
3E2 (1)
OTI1B12 (2)
OTI2B8 (2)
12 x 8-Well Microstrips (4)
96-Well Microplate (2)
96-Well Strip Plate (10)
APC (2)
APC Conjugated (4)
Azide-free (1)
Biotin Conjugated (5)
Carrier-free (2)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (5)
HRP Conjugated (4)
PE Conjugated (4)
Unconjugated (41)
aa2634-2842 (8)
aa2636-2845 (8)
aa1148-1176 (7)
pSer2054 (6)
aa955-1382 (4)
aa2634-2843 (3)
aa1-50 (2)
1990-2070 aa (1)
2770-2850 aa, C-terminal (1)
Ab-2054 (1)
C-Terminus (1)
Gln2829 (1)
Internal (1)
Lys2050 (1)
aa1-433 (1)
aa2020-2069 (1)
aa2537-2843 (1)
aa2793-C-term (1)
aa2794-2843 (1)
aa75-125 (1)
No (89)
Adherent Cell Cultures (2)
Cell Lysates (2)
Plasma (7)
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Tissue Homogenates (3)
GST, N-terminus (1)
His-T7 (3)
Myc-DDK (Flag) (2)
Human (3)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (1)
APC Antibody - Western blot of APC antibody
Select
APC Rabbit anti-Human Polyclonal (2770-2850 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
APC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
15.63 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
APC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$748
APC Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
APC Rabbit anti-Human Polyclonal (aa2794-2843) Antibody
Mouse, Rat, Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
APC Antibody - Detection of Human APC by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-APC used at a dilution of 1:250.
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APC Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC
Unconjugated
2.5 µg/$295; 100 µl/$532
APC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
APC Antibody - Immunohistochemical analysis of APC staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
APC Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
APC Antibody - Western blot analysis of APC (pS2054) expression in HeLa (A); Caco2 (B); SW480 (C); MCF7 (D); SP2/0 (E); PC12 (F) whole cell lysates.
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APC Rabbit anti-Human Polyclonal (pSer2054) Antibody
Mouse, Rat, Pig, Human, Monkey
WB
Unconjugated
100 µl/$315
APC ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
APC Antibody - Immunofluorescence of monoclonal antibody to APC on HeLa cell . [antibody concentration 10 ug/ml]
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APC Mouse anti-Human Monoclonal (3E2) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
APC Antibody - Immunohistochemical analysis of APC staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
APC Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
Select
APC Rabbit anti-Human Polyclonal (aa1148-1176) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
APC Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
APC Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
APC Antibody - 1:100 staining human Rectum tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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APC Rabbit anti-Human Polyclonal (pSer2054) Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
APC Antibody - IHC of APC (Q2829) pAb in paraffin-embedded human lung carcinoma tissue.
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APC Rabbit anti-Human Polyclonal (Gln2829) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
APC Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-APC mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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APC Mouse anti-Human Monoclonal (aa955-1382) (OTI2B8) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
APC Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-APC mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
APC Mouse anti-Human Monoclonal (aa955-1382) (Carrier-free) (OTI2B8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
APC Antibody - Immunohistochemistry of paraffin-embedded Human lung using APC Polyclonal Antibody at dilution of 1:200 (40x lens).
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APC Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
APC Protein - Recombinant Adenomatosis Polyposis Coli Protein By SDS-PAGE
Select
E. coli
His-T7
26.2 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
APC Protein - Recombinant Adenomatosis Polyposis Coli Protein By SDS-PAGE
Select
E. coli
His-T7
25.9 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
APC ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
APC Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using APC (Phospho-Ser2054) Antibody. The picture on the right is blocked with the phospho peptide.
Select
APC Rabbit anti-Human Polyclonal (pSer2054) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
APC Rabbit anti-Human Polyclonal (1990-2070 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
APC Mouse anti-Human Monoclonal (aa1-433) Antibody
Human
IHC, IHC-Fr, WB
Unconjugated
50 µg/$558
APC Antibody - Western blot analysis of extracts from HUVEC cells, treated with PMA (125ng/ml, 30mins), using APC (Phospho-Ser2054) antibody.
Select
APC Rabbit anti-Human Polyclonal (pSer2054) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
Viewing 1-25 of 89 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).