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CDKN1B / p27 Kip1
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
| Gene Name: | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| Synonyms: | CDKN1B, KIP1, MEN1B, P27 Kip1, p27KIP1, MEN4, CDKN4 |
| Target Sequences: | NM_004064 NP_004055.1 P46527 |
Publications (6)
1
Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T, Tsurumi T. The Journal of biological chemistry. 2009 284:18923-31. (WB)
[PubMed:19451650]
[PMC:PMC2707218]
2
Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X. The Journal of biological chemistry. 2012 287:2090-8.
[PubMed:22139837]
[PMC:PMC3265888]
3
Dasatinib, a small molecule inhibitor of the Src kinase, reduces the growth and activates apoptosis in pre-neoplastic Barrett's esophagus cell lines: evidence for a noninvasive treatment of high-grade dysplasia. Landon J Inge, Aaron J Fowler, Kimberly M Paquette, Amanda L Richer, Nhan Tran, Ross M Bremner. The Journal of thoracic and cardiovascular surgery. 2013 February;145:531-8. [Full Text Article]
[PubMed:23142123]
Related Antibodies: LS-C335975.
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Products
Antibodies
(219)
Proteins
(13)
ELISA Kits
(10)
Type
Cell-Based
(1)
Cell-Based Phosphorylation
(3)
Over-Expression Lysate
(2)
Primary
(219)
Recombinant
(11)
Sandwich
(5)
Sandwich CLIA
(1)
Target
CDKN1B / p27 Kip1
(242)
Reactivity
Human
(207)
Mouse
(98)
Rat
(71)
Bovine
(6)
Cat
(1)
Chimpanzee
(3)
Dog
(6)
Gibbon
(3)
Guinea pig
(3)
Hamster
(7)
Horse
(1)
Monkey
(17)
Non-Human Primate
(1)
Pig
(4)
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(9)
Rodent
(3)
Application
IHC
(94)
IHC-Fr
(3)
IHC-P
(32)
WB
(160)
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(15)
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(36)
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(109)
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(5)
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(28)
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(22)
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rabbit
(176)
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(40)
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(1)
Isotype
IgG
(139)
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(9)
IgG1,k
(26)
IgG2a
(2)
Clonality
monoclonal mc
(40)
polyclonal pc
(179)
Clone
1373CT407.103.103
(1)
3D8
(2)
4B4-E6
(1)
ABT-p27
(1)
AT7B9
(1)
DCS72.F6
(1)
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(4)
DCS-72.F6 + KIP1/769
(1)
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(3)
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(3)
SPM348
(2)
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(6)
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12 x 8-Well Microstrips
(1)
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(7)
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(2)
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(1)
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(15)
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(18)
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(18)
BSA-free
(6)
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(16)
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(16)
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(15)
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(5)
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(2)
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(133)
Epitope
pThr187
(24)
pThr198
(14)
pSer10
(11)
C-Terminus
(10)
pSer140
(9)
pThr157
(9)
pSer178
(8)
aa1-30
(7)
aa147-176
(7)
aa165-194
(7)
pSer83
(7)
pThr170
(7)
pThr197
(7)
140-220 aa
(2)
1-80 aa
(1)
100-180 aa
(1)
120-200 aa
(1)
130-210 aa
(1)
Ab-157
(1)
Ala181
(1)
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aa1-198
(1)
aa1-50
(1)
aa10-198
(1)
aa100-170
(1)
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(1)
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(1)
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(1)
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(1)
aa175-197
(1)
aa185-198
(1)
aa81-113
(1)
aa83-204
(1)
p10
(1)
p198
(1)
Publications
No
(238)
Yes
(4)
Sample Type
Adherent Cell Cultures
(4)
Cell Culture Supernatants
(1)
Cell Lysates
(1)
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(5)
Serum
(5)
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(3)
Tag
6His, N-terminus
(3)
DDK,C-terminus
(1)
GST
(1)
GST, N-terminus
(2)
His
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His-T7, N-terminus
(1)
Myc-DDK (Flag)
(3)
Species
Human
(11)
Mouse
(1)
Source
293T Cells
(1)
E. coli
(6)
HEK 293 Cells
(2)
Sf9 Cells
(1)
Wheat Germ Extract
(3)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(2)
CDKN1B / p27 Kip1 Goat anti-Human Polyclonal (aa153-165) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (4B4-E6) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$485
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (130-210 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr187) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (140-220 aa) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CDKN1B / p27 Kip1 Mouse anti-Mouse Monoclonal (DCS-72.F6) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
CDKN1B / p27 Kip1 Mouse anti-Mouse Monoclonal (Ready-to-Use) (DCS-72.F6) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
CDKN1B / p27 Kip1 Mouse anti-Mouse Monoclonal (Azide-free, BSA-free) (DCS-72.F6) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr187) Antibody
IHC, WB
Unconjugated
100 µl/$431
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr187) Antibody
Human
WB
Unconjugated
400 µl/$393
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$688
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (SX53G8) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$332
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr187) Antibody
Mouse, Dog, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
Cancer Pathology
Cancer
CDKN1B / p27 Kip1 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$460
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (KIP1/769) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (Ready-to-Use) (KIP1/769) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (KIP1/769) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (KIP27-1) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (KIP27-1) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (Ready-to-Use) (KIP27-1) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
CDKN1B / p27 Kip1 Rat anti-Human Monoclonal (aa1-198) Antibody
Mouse, Rat, Human
IHC
Unconjugated
100 µg/$896
CDKN1B / p27 Kip1 Rabbit anti-Human Polyclonal (pThr198) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CDKN1B / p27 Kip1 Mouse anti-Mouse Monoclonal (Azide-free, BSA-free) (DCS-72.F6 + KIP1/769) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
CDKN1B / p27 Kip1 Mouse anti-Human Monoclonal (Ready-to-Use) (SX53G8) Antibody
Mouse, Rat, Human, Monkey
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Ready-to-Use
7 ml/$574
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of 242
product results
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