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| Catalog Number | Size | Price |
|---|---|---|
| LS-B14422-100 | 100 µl (0.2 mg/ml) | $485 |
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2 of 2
PathPlus™ Polyclonal Rabbit anti‑Human CTNND1 / p120 Catenin Antibody (aa891‑C‑term, IHC, WB) LS‑B14422
PathPlus™ Polyclonal Rabbit anti‑Human CTNND1 / p120 Catenin Antibody (aa891‑C‑term, IHC, WB) LS‑B14422
Note: This antibody replaces LS-C287812
Antibody:
CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa891-C-term) Antibody
Application:
IHC, IHC-P, WB, IP
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
CTNND1 / p120 Catenin Rabbit anti-Human Polyclonal (aa891-C-term) Antibody
Application:
IHC, IHC-P, WB, IP
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Specifications
Description
CTNND1 (p120 Catenin, Catenin delta 1) is a member of the Armadillo protein family, which functions in adhesion between cells and signal transduction. CTNND1 stabilizes the epithelial adherens junction, an E-cadherin based complex that controls tissue integrity. Loss of CTNND1 is associated with cancer progression. Along with downregulation of e-cadherin, cytoplasmic IHC staining is observed in lobular breast carcinomas (and not invasive ductal carcinomas), with redistribution from the membrane to the cytoplasm. In normal epithelial cells as well as in invasive ductal carcinomas of the breast, CTNND1 staining is expected to be on the cell membrane.
References: J Cell Sci 2013 126:3515; J Mamm Gland Biol Neopl 2016 21(3):81; Li, 2014; Li, 2010; Histopath 2016 68:57; Am J Surg Path 2007 31:427.
Target
Human CTNND1 / p120 Catenin
Synonyms
CTNND1 | CAS | Catenin delta-1 | CTNND | KIAA0384 | p120 | p120(CAS) | p120(CTN) | p120CAS | p120CTN | p120 catenin | p120-catenin
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Immunogen
A portion of GeneID: 1500 corresponding to amino acids between 891 and the C-Terminus of UniprotID: O60716
Epitope
aa891-C-term
Specificity
Region between residue 891 and the C-terminus (residue 941) of human catenin (cadherin-associated protein), delta 1 using the numbering given in entry NP_001322.1 (GeneID 1500).
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
- Western blot (1:2000 - 1:10000)
- Immunoprecipitation (2 - 5 µg/mg lysate)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
IHC: Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Manufacturer
Bethyl Laboratories, Inc.
Presentation
TBS, 0.09% Sodium Azide, 0.1% BSA
Storage
Store at 2-8°C for up to one year.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CTNND1 / p120 Catenin
Validation
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CTNND1 / p120 Catenin Antibody (aa891-C-term) for IHC, WB/Western, IP LS-B14422 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot, Immunoprecipitation
Species:
Human, Monkey, Mouse
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, ICC, Immunofluorescence, Western blot, Immunoprecipitation
Species:
Human, Mouse, Rat
Applications:
ICC, Western blot, Flow Cytometry
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/23/2024
Date Requested: 11/23/2024
