Human APP / Beta Amyloid Precursor

Rabbit

Human, Mouse (tested or 100% immunogen sequence identity)

IgG Polyclonal

FITC. Also available conjugated with APC, Biotin, HRP, PE.

Immunoaffinity purified

Unmodified

Synthetic peptide derived from the C-Terminus of the human and mouse amyloid-beta precursor protein (APP695).

Reacts with mouse and human APP. On Western blots, this antibody identifies a specific band representing the full-length protein at ~100kD, and a band at ~10-12kD representing the C99 C-terminal cleavage fragment. A major non-specific band has been observed at ~50kD in mouse brain homogenates. Reactivity has been confirmed with APLP2 (amyloid precursor-like protein 2) -/- knock-out and wild type mouse brain homogenates, and APP695 C99 (C-terminal fragment)-transfected HEK293 cell lysates by Western blotting. Negative control tests with APP -/- knock-out and APP/APLP2 double knock-out mice have confirmed the specificity of this antibody; neither of the target bands were identified in these test samples. Reactivity has also been confirmed with human Alzheimer's brain tissue by immunohistochemistry.

• IHC
• Western blot
• Immunoprecipitation
• Applications tested for the base form of this product only

PBS, pH 7.2, No preservatives added

Store at 4°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P05067 NCBI: NM_000484 NP_000475.1