Target
Human BACE2
Synonyms
BACE2 | 56 kDa aspartic-like protease | AEPLC | ALP56 | Aspartic-like protease 56 kDa | APL56 | BAE2 | Beta-secretase 2 | ASP21 | CDA13 | DRAP | Memapsin-1 | Asp 1 | ASP1 | Aspartyl protease 1 | Theta-secretase | Beta secretase 2 | CEAP1 | Down region aspartic protease
Reactivity
Human
(tested or 100% immunogen sequence identity)
Conjugations
Horseradish Peroxidase.
Also available
Unconjugated or conjugated with
FITC,
Biotin.
Immunogen
Recombinant Human Beta-secretase 2 protein (84-157AA)
Specificity
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.