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| Catalog Number | Size | Price |
|---|---|---|
| LS-C500779-50 | 50 µg | $294 |
| LS-C500779-100 | 100 µg | $360 |
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Polyclonal Rabbit anti‑Human BECN1 / Beclin‑1 Antibody (IHC, IF, WB) LS‑C500779
Polyclonal Rabbit anti‑Human BECN1 / Beclin‑1 Antibody (IHC, IF, WB) LS‑C500779
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
Beclin-1 antibody LS-C500779 is an unconjugated rabbit polyclonal antibody to Beclin-1 (BECN1) from human. It is reactive with human and mouse. Validated for ELISA, IF, IHC and WB.
Target
Human BECN1 / Beclin-1
Synonyms
BECN1 | ATG6 | Beclin 1 | Beclin 1, autophagy related | Beclin1 | GT197 | Protein GT197 | VPS30 | Beclin-1
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Recombinant Human Beclin-1 protein (1-100AA)
Specificity
Plays a central role in autophagy (PubMed:23184933). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed:25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed:9765397). May play a role in antiviral host defense.
Applications
- IHC
- Immunofluorescence
- Western blot
- ELISA
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About BECN1 / Beclin-1
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Featured Products
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, ICC, Immunofluorescence, Western blot, ELISA
Species:
Human, Rat, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Species:
Human, Mouse
Applications:
IHC, Western blot, Flow Cytometry, ELISA
Species:
Human, Mouse, Rat, Bovine, Pig, Primate
Applications:
IHC, IHC - Paraffin, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
