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| Catalog Number | Size | Price |
|---|---|---|
| LS-C121911-250 | 250 µl | $860 |
Monoclonal Mouse anti‑Human GZMB / Granzyme B Antibody (clone GRB‑7, IHC, WB) LS‑C121911
Monoclonal Mouse anti‑Human GZMB / Granzyme B Antibody (clone GRB‑7, IHC, WB) LS‑C121911
Antibody:
GZMB / Granzyme B Mouse anti-Human Monoclonal (GRB-7) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
GZMB / Granzyme B Mouse anti-Human Monoclonal (GRB-7) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Granzyme B antibody LS-C121911 is an unconjugated mouse monoclonal antibody to human Granzyme B (GZMB). Validated for IHC and WB.
Target
Human GZMB / Granzyme B
Synonyms
GZMB | CCPI | CGL-1 | Cathepsin G-like 1 | CSP-B | CTLA-1 | CTLA1 | CGL1 | CSPB | Fragmentin 2 | GRB | HLP | Human lymphocyte protein | Fragmentin-2 | SECT | Lymphocyte protease | T-cell serine protease 1-3E | C11 | CTSGL1 | Cytotoxic serine protease B | Granzyme B | Granzyme-2
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG2a
Monoclonal
Clone
GRB-7
Conjugations
Unconjugated
Purification
Tissue culture supernatant
Modifications
Unmodified
Immunogen
Human granzyme B.
Specificity
Recognizes the 33kD human serine protease granzyme B. Does not react with human granzyme A. It is used as a marker for NK-cells and activated cytotoxic T-cells (CTL). This protease is localized in cytoplasmic granules and gives a granular staining pattern. Granzyme B is involved in target cell apoptosis during lymphocyte mediated cyto-toxicity. Exocytosis of granzyme containing granules in the cytoplasm of the target cell will lead to induction of DNA fragmentation and apoptosis of the target cell.
Applications
- IHC
- IHC - Paraffin
- IHC - Frozen
- Western blot (1:20)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Suitable for use in Western Blot and Immunohistochemistry: 1:20 Stains granzyme B expressing lymphocytes in sections of sublimate formaldehyde as well as formalin fixed paraffin embedded tissues. Does not react with other cell types. Can not be used on frozen sections. Pretreatment with 0.1 M sodium citrate, for 10 min at 100°C in a microwave oven is advised.
Presentation
0.02% Sodium Azide, 0.1% BSA
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GZMB / Granzyme B
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Featured Products
Species:
Human
Applications:
IHC, IHC - Frozen, Immunofluorescence, Immunoprecipitation, Flow Cytometry, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin
Species:
Human, Monkey
Applications:
ELISA
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/21/2024
Date Requested: 12/21/2024
