Virus HPV16 E7

Mouse

Virus (tested or 100% immunogen sequence identity)

IgG2a Monoclonal

716-D1

Unconjugated

Affinity purified

Unmodified

Oncoprotein E7 from human papillomavirus 16.

Recognizes both the monomer and dimer forms of the E7 oncoprotein of human papilloma virus 16. Human papillomavirus (HPV) is a diverse group of DNA-based viruses that infect skin and mucous membranes of humans and animals. Some HPV types are the causative agents of cervical cancer, with types 16 and 18 being particularly high-risk. The viral proteins E6 and E7 disrupts normal cell cycle regulation by interacting with p53 (a tumor-suppressing transcription factor) and Rb (retinoblastoma protein, also a tumor-suppressor). E7 particularly binds to Rb and histone deacetylases, resulting in activation of the E2F genes, which code for a family of transcription factors. The viral proteins E6 and E7 might be of particular interest in the development of therapeutic vaccines, since they are expressed early in viral infection. Reacts with both the monomer and dimer forms of the E7 protein of HPV-18.

• Western blot
• ELISA

PBS, less than 0.1% Sodium Azide

Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P03129 NCBI: NP_041326.1