MLH1

Mouse

Human, Rat, Hamster (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

G168-15

Unconjugated

Unmodified

Full length recombinant MLH.

The G168-15 antibody recognizes the human and mouse MLH1 (80-85kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. cross reacts with human, hamster and rat

• IHC
• IHC - Paraffin

Supplied as a liquid containing sodium azide as a preservative

Store at 2°C to 8°C. Do not freeze.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P40692 NCBI: NM_000249 NP_000240.1