Human NOTCH1

Rabbit

Human, Mouse, Rat, Bovine, Guinea pig, Hamster, Horse, Sheep (tested or 100% immunogen sequence identity)

Bat, Dog, Chicken, Xenopus (at least 90% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the middle region of human Notch1 (QHSYSSPVDNTPSHQLQVPE, aa2487-2506 of UniProt P46531). Percent identity by BLAST analysis: Human, Mouse, Rat, Sheep, Bovine, Hamster, Horse, Guinea pig (100%); Cat, Bat, Dog (95%); Opossum, Zebra finch, Chicken, Xenopus (90%); Platypus, Newt, Medaka (85%); Trout, Pufferfish, Stickleback (80%).

aa2487-2506

Human NOTCH1

• Western blot (0.5 - 1 µg/ml)

Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in 200 ul sterile distilled water

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P46531 NCBI: NM_017617 NP_060087.3