Mouse NOTCH1

Mouse

Mouse (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

mN1A

Unconjugated. Also available conjugated with RPE, FITC.

Protein G purified

Unmodified

Synthetic peptide corresponding to cdc10-NCR region within mouse Notch1

Specific for mouse Notch1, a single transmembrane receptor which is expressed in a range of cells including hematopoietic cells in mouse fetal liver, adult thymus and bone marrow. Notch1 plays a role in embryonic development and tissue homeostasis in the adult. Recent work has suggested a further role for this receptor in the regulation of lymphopoiesis and myelopoiesis. Following ligand binding, Notch1 is cleaved in the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus, where it plays a role in the modulation of gene expression.

• IHC
• IHC - Frozen (1:50 - 1:200)
• Western blot
• Flow Cytometry

Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Membrane permeabilization is required for this application. Method sheets are available on request.

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P46531 NCBI: NM_017617 NP_060087.3