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| Catalog Number | Size | Price |
|---|---|---|
| LS-C390996-7 | 7 ml | $574 |
1 of 2
2 of 2
Monoclonal Mouse anti‑Human TAGLN / Transgelin / SM22 Antibody (clone TAGLN/247, Ready‑to‑Use, IHC, IF) LS‑C390996
Monoclonal Mouse anti‑Human TAGLN / Transgelin / SM22 Antibody (clone TAGLN/247, Ready‑to‑Use, IHC, IF) LS‑C390996
Antibody:
TAGLN / Transgelin / SM22 Mouse anti-Human Monoclonal (Ready-to-Use) (TAGLN/247) Antibody
Application:
IHC, IHC-P, IF, Flo
Reactivity:
Human, Mouse, Bovine, Pig, Rabbit
Format:
Unconjugated, Ready-to-Use
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
TAGLN / Transgelin / SM22 Mouse anti-Human Monoclonal (Ready-to-Use) (TAGLN/247) Antibody
Application:
IHC, IHC-P, IF, Flo
Reactivity:
Human, Mouse, Bovine, Pig, Rabbit
Format:
Unconjugated, Ready-to-Use
Other formats:
Specifications
Description
SM22 antibody LS-C390996 is an unconjugated mouse monoclonal antibody to SM22 (TAGLN / Transgelin) from human. It is reactive with human, mouse, bovine and other species. Validated for Flow, IF and IHC.
Target
Human TAGLN / Transgelin / SM22
Synonyms
TAGLN | 22 kDa actin-binding protein | SMCC | TAGLN1 | WS3-10 | Transgelin | Transgelin variant 2 | SM22 | Protein WS3-10 | SM22-alpha
Host
Mouse
Reactivity
Human, Mouse, Bovine, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Clonality
IgG1,k
Monoclonal
Clone
TAGLN/247
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Ready-to-Use.
Also available Unmodified or Azide-free, BSA-free.
Immunogen
Recombinant Full-length Human Protein.
Specificity
Human TAGLN / Transgelin / SM22
Applications
- IHC
- IHC - Paraffin (1:1)
- Immunofluorescence
- Flow Cytometry
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. This mAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers. Optimal dilution of the SM22 antibody should be determined by the researcher. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 min. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Presentation
1X PBS, 0.1 mg/ml BSA, 0.05% sodium azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
About TAGLN / Transgelin / SM22
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Xenopus
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Rat, Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, Flow Cytometry
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 1/5/2025
Date Requested: 1/5/2025
