Human TFF1 / pS2

Mouse

Human, Chimpanzee (tested or 100% immunogen sequence identity)

IgG1,k Monoclonal

GE2

Unconjugated

Protein G purified

Azide-free, BSA-free. Also available Ready-to-Use.

Amino acids CFDDTVRGVPWCFYPNTIDVPPEEECEF (57-84) from the C-Terminus of human Estrogen inducible protein pS2. Percent identity by BLAST analysis: Chimpanzee (100%); Gorilla (96%); Monkey (89%); Mouse (43%); Rat (39%).

pSer2

Human TFF1 / PS2

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• Immunofluorescence (0.5 - 1 µg/ml)
• Western blot
• Immunoprecipitation
• Flow Cytometry (0.5 - 1 µg/10E6 cells)
• ELISA

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. This antibody recognizes a polypeptide of ~6.5kDa, identified as Estrogen Inducible Protein pS2. The antibody's epitope is localized between amino acids 57-84. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. Estrogen Inducible Protein pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for estrogen inducible protein pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. It is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that estrogen inducible protein pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

1X PBS

Store at 2°C to 8°C.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P04155 NCBI: NM_003225 NP_003216.1