Target
Rat THY1 / CD90
Synonyms
THY1 | CD90 antigen | CD90 | CDw90 | Thy-1 antigen | Thy-1 T-cell antigen | Thy-1 | Thy-1 cell surface antigen | Thy-1 membrane glycoprotein
Reactivity
Rat
(tested or 100% immunogen sequence identity)
Purification
Ion exchange chromatography
Specificity
Recognizes rat and mouse CD90, also known as Thy1.1, expressed on a variety of cell types including thymocytes, neuronal cells, stem cells, T lymphocytes (mouse), immature B cells (rat) and connective tissues. Since Thy1.1 is a monomorphic determinant in rat but polymorphic in mice, clone MRC Reacts with Thy1.1 mice e. g. AKR and FVB mice, but not Thy1.2 mice such as CBA and BALB/c. The affinity of the Fab of MRC OX-7 for rat Thy1 is 3 x 109m-1 and for mouse Thy1.1 is 3 x 108m-1. Clone MRC OX-7 has been demonstrated to promote neurite outgrowths on peripherin-stained sympathetic rat neurons, using fluorescence microscopy. This product is routinely tested in flow cytometry on rat thymocytes.