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| Catalog Number | Size | Price |
|---|---|---|
| LS-A1441-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain, IHC) LS‑A1441
PathPlus™ Polyclonal Rabbit anti‑Human ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain, IHC) LS‑A1441
Antibody:
ACKR4 / CCRL1 / CCR11 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Mouse, Rat, Bat, Dog, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Overview
Antibody:
ACKR4 / CCRL1 / CCR11 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Mouse, Rat, Bat, Dog, Horse, Pig, Rabbit
Format:
Unconjugated, Unmodified
Specifications
Description
Atypical chemokine receptor 4 (ACKR4) controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. ACKR4 plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. ACKR4 negatively regulates CXCR3-induced chemotaxis and regulates T-cell development in the thymus.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human ACKR4 / CCRL1 / CCR11
Synonyms
ACKR4 | C-C CKR-11 | CC-CKR-11 | CC chemokine receptor-like 1 | CCR11 | CCX CKR | C-C chemokine receptor type 11 | CKR-11 | CCRL1 | VSHK1 | CCR-11 | CCX-CKR | PPR1
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bat, Dog, Horse, Pig, Rabbit
(tested or 100% immunogen sequence identity)
Predicted
Monkey, Bovine, Hamster (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from 1st cytoplasmic domain of human CCRL1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Rat, Dog, Bat, Elephant, Panda, Horse, Rabbit, Pig (100%); Marmoset, Bovine, Hamster, Opossum (94%); Turkey, Chicken, Xenopus (81%).
Epitope
Cytoplasmic Domain
Specificity
Human CCRL1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CCR6 (63%).
Applications
- IHC
- IHC - Paraffin (24 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About ACKR4 / CCRL1 / CCR11
Validation
Brain, Amygdala
Brain, Amygdala
Brain, Alzheimer's disease senile plaque
Brain, Alzheimer's disease senile plaque
Brain, Alzheimer's disease neurofibrillary tangle
Brain, Alzheimer's disease neurofibrillary tangle
Anti-ACKR4 / CCRL1 / CCR11 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACKR4 / CCRL1 / CCR11 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACKR4 / CCRL1 / CCR11 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-ACKR4 / CCRL1 / CCR11 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CCRL1 antibody IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CCRL1 antibody IHC of human heart, cardiac myocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ ACKR4 / CCRL1 / CCR11 Antibody (Cytoplasmic Domain) for IHC LS-A1441 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human, Mouse
Applications:
ICC, Immunofluorescence, Western blot
Species:
Human, Mouse
Applications:
Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Mouse
Applications:
Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Mouse
Applications:
Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/22/2024
Date Requested: 12/22/2024
