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| Catalog Number | Size | Price |
|---|---|---|
| LS-B746-50 | 50 µg (0.5 mg/ml) | $545 |
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PathPlus™ Polyclonal Rabbit anti‑Human BCL10 / BCL‑10 Antibody (aa5‑19, IHC, WB) LS‑B746
PathPlus™ Polyclonal Rabbit anti‑Human BCL10 / BCL‑10 Antibody (aa5‑19, IHC, WB) LS‑B746
Note: This antibody replaces LS-C26611, LS-C4134
Antibody:
BCL10 / BCL-10 Rabbit anti-Human Polyclonal (aa5-19) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
BCL10 / BCL-10 Rabbit anti-Human Polyclonal (aa5-19) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Specifications
Description
BCL10 (B-cell lymphoma/leukemia 10) is a cellular homolog of the equine herpesvirus-2 E-10 gene that functions to induce apoptosis by activating CASP9. When overexpressed, BCL10 induces JNK, p38, and NF-kB activation. BCL10 plays an important role in both activating and suppressing adaptive and innate immune signaling by connecting to various CARD scaffold proteins. BCL10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas and participates in the pathogenesis of various malignancies. In immunohistochemistry of normal tissue, BLC10 has cytoplasmic positivity in most tissues throughout the body.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Front Immunol. 2018; 9: 1539, PMID: 30022982
Target
Human BCL10 / BCL-10
Synonyms
BCL10 | Bcl-10 | B-cell CLL/lymphoma 10 | B-cell lymphoma/leukemia 10 | CARMEN | CARD-like apoptotic protein | CCARMEN | C-E10 | CIPER | Cellular-E10 | HCLAP | Cellular homolog of vCARMEN | CLAP | ME10
Host
Rabbit
Reactivity
Human, Mouse, Rat
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Immunogen
Synthetic peptide from human BCL10.
Epitope
aa5-19
Specificity
Amino acids 5-19 of human BLC10
Applications
- IHC
- IHC - Paraffin (10 - 20 µg/ml)
- Western blot
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: LS-B746 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B746 was determined to be 10 ug/ml.
Presentation
PBS, 0.02% Sodium Azide
Storage
Store at 4°C or -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About BCL10 / BCL-10
Validation
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Anti-BCL10 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-BCL10 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-BCL10 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-BCL10 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
See More About...
LSBio Ratings
PathPlus™ BCL10 / BCL-10 Antibody (aa5-19) for IHC, WB/Western LS-B746 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
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Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human, Dog
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse
Applications:
IHC, ICC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Species:
Human, Mouse
Applications:
IHC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/3/2024
Date Requested: 11/3/2024
