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| Catalog Number | Size | Price |
|---|---|---|
| LS-B4403-50 | 50 µg (0.5 mg/ml) | $460 |
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PathPlus™ Polyclonal Goat anti‑Human CANX / Calnexin Antibody (aa200‑250, IHC, IF, WB) LS‑B4403
PathPlus™ Polyclonal Goat anti‑Human CANX / Calnexin Antibody (aa200‑250, IHC, IF, WB) LS‑B4403
Note: This antibody replaces LS-C108122
Antibody:
CANX / Calnexin Goat anti-Human Polyclonal (aa200-250) Antibody
Application:
IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Monkey, Mouse, Bat, Bovine, Dog, Horse, Pig, Rabbit, Chicken
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
CANX / Calnexin Goat anti-Human Polyclonal (aa200-250) Antibody
Application:
IHC-P, IF, WB, Peptide-ELISA
Reactivity:
Human, Monkey, Mouse, Bat, Bovine, Dog, Horse, Pig, Rabbit, Chicken
Format:
Unconjugated, Unmodified
Specifications
Description
CANX (also called calnexin) is a calcium-binding molecular chaperone protein that is involved in facilitating the assembly and folding of newly synthesized N-linked glycoproteins. It is a stress-induced protein located in the endoplasmic reticulum membrane. It is also found in melanosomes, where it appears to be involved in melanosome biogenesis. CANX is broadly expressed in normal and diseased tissues, and expression may be increased or decreased in certain types of cancers.
References: EMBO J. 2012;31(7):1823-1835. doi: 10.1038/emboj.2012.15; J Proteome Res. 2003;2(1):69-79. PMID: 12643545; J Transl Med. 2016;14(1):196. doi: 10.1186/s12967-016-0948-z; Cancer Lett. 2004;203(2):225-231. PMID: 14732231; Lung Cancer. 2015;90(2):342-345. doi: 10.1016/j.lungcan.2015.08.015; J Cell Mol Med. 2017;21(12):3141-3149. doi: 10.1111/jcmm.13413.
Target
Human CANX / Calnexin
Synonyms
CANX | CNX | Calnexin | IP90 | p90
Host
Goat
Reactivity
Human, Monkey, Mouse, Bat, Bovine, Dog, Horse, Pig, Rabbit, Chicken
(tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Immunogen
A synthetic peptide corresponding to residues near the N-Terminus of human Calnexin was used as an immunogen.
Epitope
aa200-250
Specificity
Human CANX / Calnexin. Reported variants represent identical protein (NP_001019820.1, NP_001737.1).
Applications
- IHC - Paraffin (5 µg/ml)
- Immunofluorescence (5 µg/ml)
- Western blot (0.3 - 1 µg/ml)
- Peptide Enzyme-Linked Immunosorbent Assay (1:32000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Western Blot: Approx. 100kD band observed in Mouse Heart, Human Brain (Cerebellum), NIH3T3 and HeLa lysates (calculated MW of 67.6kD according to Human NP_001737.1 and 67.2kD according to Mouse NP_001103969.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Oliver et al., J Biol Chem. 1996 Jun 7;271(23):13691-6., PMID: 8662691). Recommended concentration: 0.3-1 ug/ml.
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CANX / Calnexin
Validation
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CANX / Calnexin Antibody (aa200-250) for IHC, IF/Immunofluorescence, WB/Western LS-B4403 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot, Immunoprecipitation
Species:
Human, Monkey, Mouse, Rat, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Monkey, Mouse, Rat, Dog
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/25/2024
Date Requested: 11/25/2024
