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Catalog Number Size Price
LS-B16702-50 50 µg (0.5 mg/ml) $460 
CD44 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - CD44 antibody E12255 (0.03 ug/ml) staining of U-2 OS lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
CD44 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - CD44 antibody E12255 (0.03 ug/ml) staining of U-2 OS lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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PathPlus™ Polyclonal Goat anti‑Human CD44 Antibody (aa149‑163, IHC, WB) LS‑B16702

PathPlus™ Polyclonal Goat anti‑Human CD44 Antibody (aa149‑163, IHC, WB) LS‑B16702

Note: This antibody replaces LS-C205002
Antibody:
CD44 Goat anti-Human Polyclonal (aa149-163) Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-B16702-50
Toll Free North America
(800) 227-6666
For Research Use Only

Overview

Antibody:
CD44 Goat anti-Human Polyclonal (aa149-163) Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
CD44 is a glycoprotein receptor that is involved in cell adhesion, cell migration, and other cell-cell interactions. It plays a role in many cellular functions including lymphocyte activation, recirculation, and homing, hematopoiesis, and the progression and metastasis of cancer cells. CD44 exists in several isoforms, and the main isoform is expressed ubiquitously in the cytoplasm and membrane of various cell types throughout the body in normal and diseased tissues including cancers and autoimmune diseases. The absence of the main isoform, or the presence of certain other isoforms in cancer cells, is associated with poor prognosis. In immunohistochemistry, CD44 is a marker for squamous epithelium, and in cancer it can distinguish reactive urothelium from carcinoma in situ. It is positive in colorectal cancer, glioma, oligodendroglioma, prostatic small cell carcinoma, squamous cell and adneosquamous carcinoma. Loss of CD44 is a general marker of poor prognosis in cancer. References: Front Cell Dev Biol. 2017;5:18. doi: 10.3389/fcell.2017.00018; Saudi Med J. 2015;36(3):273-279. doi: 10.15537/smj.2015.3.9622; Arch Immunol Ther Exp (Warsz). 2004;52(1):13-26. PMID: 15053229; Pathol Int. 2012;62(7):463-470. doi: 10.1111/j.1440-1827.2012.02823.x; Recent Pat Inflamm Allergy Drug Discov. 2017;11(2):77-91. doi: 10.2174/1872213X11666170907111858; Stem Cells Transl Med. 2015;4(9):1033-1043. doi: 10.5966/sctm.2015-0048.
Target
Human CD44
Synonyms
CD44 | CDW44 | CD44 antigen | Cell surface glycoprotein CD44 | CSPG8 | ECMR-III | Epican | HUTCH-I | LHR | MDU2 | MC56 | MIC4 | Hermes antigen | Hyaluronate receptor | Phagocytic glycoprotein 1 | PGP-1 | PGP-I | Pgp1 | Phagocytic glycoprotein I | MDU3 | CD44R | HCELL | Heparan sulfate proteoglycan
Host
Goat
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Immunogen
Peptide with sequence C-NRDGTRYVQKGEYRT, from the internal region of the protein sequence according to NP_000601.3NP_001001389.1NP_001001390.1NP_001001391.1NP_001001392.1NP_001189484.1NP_001189485.1NP_001189486.1.
Epitope
aa149-163
Specificity
Human CD44. This antibody is expected to recognize reported isoforms 1, 2, 3, 4, 6, 7, 8 (NP_000601.3; NP_001001389.1; NP_001001390.1; NP_001001391.1; NP_001189484.1; NP_001189485.1; NP_001189486.1).
Applications
  • IHC - Paraffin (5 µg/ml)
  • Western blot (0.01 - 0.03 µg/ml)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:128000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 75-82kD band observed in lysates of cell line U-2 OS (calculated MW of 81.5kD according to NP_000601.3 and 76.6 according to NP_001001389.1). Recommended concentration: 0.01-0.03 ug/ml.
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD44
P16070 NM_000610 NP_000601.3

Validation

CD44 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD44 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD44 Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ CD44 Antibody (aa149-163) for IHC, WB/Western LS-B16702 has an LSBio Rating of
Laboratory Validation Score (5)

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 10/31/2024