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Catalog Number Size Price
LS-A42-50 50 µg (1 mg/ml) $440 
DRD1 / Dopamine Receptor D1 Antibody - Anti-DRD1 antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PathPlus™ Polyclonal Rabbit anti‑Human DRD1 / Dopamine Receptor D1 Antibody (Extracellular Domain, IHC) LS‑A42

PathPlus™ Polyclonal Rabbit anti‑Human DRD1 / Dopamine Receptor D1 Antibody (Extracellular Domain, IHC) LS‑A42

Antibody:
DRD1 / Dopamine Receptor D1 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$440
LS-A42-50

Toll Free North America
(800) 227-6666
For Research Use Only

Overview

Antibody:
DRD1 / Dopamine Receptor D1 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
DRD1 (Dopamine receptor D1) is a G-protein coupled receptor and the most abundant dopamine receptor found in the central nervous system. DRD1 is primarily found in the dorsal striatum in the brain, where it regulates neuronal growth and modulates behavioral responses. In the hippocampus, DRD1 works with GHSR1a (growth hormone secretagogue receptor) to promote synaptic formation and this interaction can be disrupted and lead to synaptic injury in Alzheimer’s disease. Agonists to DRD1 are of interest in the treatment of neuropsychiatric diseases and neurodegenerative diseases including Parkinson’s, and can be associated with cognitive enhancements. In immunohistochemistry, DRD1 is expected to have membranous positivity in the brain. References: Neuropsychopharmacology. 40 (2): 446–453, PMID: 25074637; Clin Neuropharmacol. 21 (6): 339–43. PMID 9844789; Science Translational Medicine. 2019. Vol. 11 (505): eaav6278, DOI: 10.1126/scitranslmed.aav6278
Target
Human DRD1 / Dopamine Receptor D1
Synonyms
DRD1 | D(1A) dopamine receptor | DRD1A | DADR | D1a receptor
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from 2nd extracellular domain of human DRD1. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon, Marmoset (95%); Elephant (90%); Dog, Rabbit (85%); Horse (80%).
Epitope
Extracellular Domain
Specificity
Human DRD1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Failed Applications
  • IHC - Frozen
  • ICC
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About DRD1 / Dopamine Receptor D1
P21728 NM_000794 NP_000785.1

Validation

DRD1 / Dopamine Receptor D1 Antibody - Anti-DRD1 antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-DRD1 antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-DRD1 antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ DRD1 / Dopamine Receptor D1 Antibody (Extracellular Domain) for IHC LS-A42 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 11/5/2024