ERG (ETS Transcription Factor) is a member of the erythroblast transformation-specific family of transcription factors that act as key regulators of embryogenesis, differentiation, cell proliferation, angiogenesis, inflammation, and apoptosis. This protein contains an ETS DNA-binding domain and a PNT domain which is implicated in the self-association of chimeric oncoproteins. ERG is required for platelet adhesion to the endothelium during vascular remodeling, and is involved in the maturation of megakaryocytes. Chromosomal translocations between ERG and various genes are implicated in prostate cancer, Ewing’s sarcoma, and acute myeloid leukemia. The normal protein is expressed in the nucleus and cytoplasm of a variety of tissues. References: Medical Epigenetics 2015 3:19; Biochem Soc Trans 2009 37(pt6):1248; Science 2005 310:644