FGF2 (basic fibroblast growth factor) is an FGF family protein involved in angiogenesis, hematopoiesis and nervous system differentiation and function. FGF2 promotes smooth muscle cell growth, tissue repair and wound healing. FGF2 is potentially a useful marker for malignancy in oral squamous cell carcinoma, as expression is correlated with malignant transformation. In immunohistochemistry of normal tissue, FGF2 has nuclear and secreted positivity throughout the central nervous system, and is found in muscle, soft tissue, immune tissues, and at lower levels with primarily nuclear localization in other tissues. References: Wiley Interdiscip Rev Dev Biol. 2015 May; 4(3): 215–266, PMID: 25772309; Endocrine Reviews. 1997. 18(1):26–45, DOI:10.1210/edrv.18.1.0292; PLoS One. 2015 Oct 14;10(10):e0138801, PMID: 26465941;