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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16243-100 | 100 µg (200 µg/ml) | $525 |
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PathPlus™ Recombinant Monoclonal Mouse anti‑Human GH / Growth Hormone Antibody (clone rGH/1450, aa58‑187, IHC) LS‑B16243
PathPlus™ Recombinant Monoclonal Mouse anti‑Human GH / Growth Hormone Antibody (clone rGH/1450, aa58‑187, IHC) LS‑B16243
Note: This antibody replaces LS-C751159
Antibody:
GH / Growth Hormone Mouse anti-Human Recombinant Monoclonal (aa58-187) (rGH/1450) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
GH / Growth Hormone Mouse anti-Human Recombinant Monoclonal (aa58-187) (rGH/1450) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
Growth Hormone (GH1, somatotropin) is a peptide hormone secreted by the pituitary gland that has anabolic functions in development to stimulate cell reproduction, regeneration and growth. Antibodies to GH1 and other hormones (prolactin, thyroid stimulating hormone) can help classify pituitary tumors, as roughly 15-20% of pituitary adenomas produce growth hormone. In immunohistochemistry of normal tissue, GH is positive in the cytoplasm of anterior pituitary gland cells and the placenta.
References: PLoS One. 2017 Jul 10;12(7):e0180039, PMID: 28692683; Front Endocrinol (Lausanne). 2015 Jun 12;6:97, PMID: 26124750; Neurosurg Focus. 2010 Oct;29(4):E2, PMID: 20887127; ISRN Endocrinol. 2013;2013:723432, PMID: 23401791; Arch Pathol Lab Med. 2017 Jan;141(1):104-112, PMID: 27227698
Target
Human GH / Growth Hormone
Synonyms
GH1 | Growth hormone | GH | GHN | IGHD1B | GH-N | Pituitary growth hormone | Growth hormone 1 | Somatotropin
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG1,k
Recombinant Monoclonal
Clone
rGH/1450
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified.
Also available Azide-free, Carrier-free.
Immunogen
A recombinant fragment (around aa 58-187) of human Growth Hormone (GH) protein. Antigen Molecular Weight: 20 kDa
Epitope
aa58-187
Specificity
Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly).
Applications
- IHC - Paraffin (1:100)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistology (Formalin-fixed - 0.5-1 ug/ml for 30 min at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GH / Growth Hormone
Validation
Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Pituitary: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ GH / Growth Hormone Antibody (aa58-187, clone rGH/1450) for IHC LS-B16243 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse
Applications:
IHC - Paraffin, ICC, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Bovine, Human
Applications:
IHC, IHC - Paraffin, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
