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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16103-0.05 | 0.05 mg (1 mg/ml) | $460 |
1 of 2
2 of 2
PathPlus™ Monoclonal Mouse anti‑Human GYPA / CD235a / Glycophorin A Antibody (clone JC159, aa1‑50, IHC) LS‑B16103
PathPlus™ Monoclonal Mouse anti‑Human GYPA / CD235a / Glycophorin A Antibody (clone JC159, aa1‑50, IHC) LS‑B16103
Note: This antibody replaces LS-C662915
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
GYPA (Glycophorin A) is a sialoglycoprotein found on erythrocyte membranes that bears the antigenic determinants for the MNS blood group system. GYPA is also a receptor for a number of viruses such as hepatitis A and influenza and is a target of invasion by the parasite Plasmodium falciparum. In immunohistochemistry, it has membranous staining in erythroblasts and erythroid cells. In cancer, it is used to identify the M6 subtype of acute myeloblastic leukemia and it is also positive in erythroleukemia.
References: Hum Genet. 2018 Feb; 137(2):151-160, PMID: 29362874; Biochem. J. 1983 Jan. 209 (1): 273–6. doi:10.1042/bj2090273, PMID: 6342608; Journal of Human Genetics. 2007 Mar. Volume 52, pages 476–479, DOI: 10.1007/s10038-007-0133-6
Target
Human GYPA / CD235a / Glycophorin A
Synonyms
GYPA | CD235a | CD235a antigen | Glycophorin A (MN blood group) | Glycophorin A, GPA | Glycophorin-A | GPA | GPErik | GPSAT | Glycophorin MiV | Glycophorin SAT | HGpMiX | HGpMiXI | HGpMiV | HGpSta(C) | Glycophorin MiI | GpMiIII | MN | HGpMiIII | MN sialoglycoprotein | Sialoglycoprotein alpha | Mi.V glycoprotein (24 AA) | PAS-2 | Glycophorin A | Glycophorin Sta type C | MNS
Host
Mouse
Reactivity
Human, Rat
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Monoclonal
Clone
JC159
Purification
Purified by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
Modifications
Unmodified
Immunogen
Membrane preparation from splenic hairy cell leukemia.
Epitope
aa1-50
Specificity
The mouse monoclonal antibody JC159 recognizes an epitope in the extracellular portion of CD235a (glycophorin A), a sialoglycoprotein expressed on early erythroblasts, late erythroblasts, erythroblasts, mature erythrocytes and the cells of erythroid cell lines K562 and HEL. The antibody does not react with glycophorin B.
Applications
- IHC - Paraffin (5 µg/ml)
- IHC - Frozen
- Flow Cytometry
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, pH 7.4, 15 mM Sodium Azide
Storage
Store at 2°C to 8°C. Do not freeze.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GYPA / CD235a / Glycophorin A
Validation
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ GYPA / CD235a / Glycophorin A Antibody (aa1-50, clone JC159) for IHC, Flow LS-B16103 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
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Featured Products
Species:
Human
Applications:
IHC - Paraffin
Species:
Human
Applications:
IHC - Paraffin, IHC - Frozen, Flow Cytometry, Agglutination
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, Flow Cytometry, ELISA
Species:
Mouse
Applications:
Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Flow Cytometry, Cytotoxic Assay
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/21/2024
Date Requested: 12/21/2024
