Hairy Cell Leukemia antibodies recognize a membrane antigen on sub-populations of B-lymphocytes and were originally developed against a B-lymphoma cell line (al Saati et al, 1989). Antibodies to hairy cell leukemia stain B-cells in the follicular mantle zone and nearly all hairy cell leukemia. They are useful for differentiating hairy cell leukemia from B-cell chronic lymphocytic leukemia. They also stain follicular center-cell lymphomas, some high grade centroblastic and immunoblastic B-cell lymphomas, and splenic margin zone lymphomas with villous lymphocytes. References: al Saati et al. Blood. 1989 Nov 15;74(7):2476-85, PMID: 2679917; Leuk Res. 1996 Nov-Dec;20(11-12):909-13, PMID: 9009248; Am J Surg Pathol. 2007;31:438, PMID:17325486; American Journal of Clinical Pathology. 2011 Sep. 136(3):390–399, DOI: 10.1309/AJCP5GE1PSBMBZTW;