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| Catalog Number | Size | Price |
|---|---|---|
| LS-A1032-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human MC4R / Melanocortin 4 Receptor Antibody (N‑Terminus, IHC) LS‑A1032
PathPlus™ Polyclonal Rabbit anti‑Human MC4R / Melanocortin 4 Receptor Antibody (N‑Terminus, IHC) LS‑A1032
Antibody:
MC4R / Melanocortin 4 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, ICC
Reactivity:
Human, Monkey, Horse
Format:
Unconjugated, Unmodified
Overview
Antibody:
MC4R / Melanocortin 4 Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P, ICC
Reactivity:
Human, Monkey, Horse
Format:
Unconjugated, Unmodified
Specifications
Description
MC4R is a receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. It plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). SNPs in MC4R (such as rs17782313) are linked with obesity, and additionally are correlated with risk for breast cancer. In immunohistochemistry, MC4R has membranous and cytoplasmic positivity in most tissues throughout the body.
References: Mol Biol Rep. 2013 Dec;40(12):6657-64, PMID: 24091943
Target
Human MC4R / Melanocortin 4 Receptor
Synonyms
MC4R | Melanocortin receptor 4 | MC4-R | MC4 | MC4 receptor | Melanocortin 4 receptor
Host
Rabbit
Reactivity
Human, Monkey, Horse
(tested or 100% immunogen sequence identity)
Predicted
Guinea pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 17 amino acid peptide from N-Terminus extracellular domain of human MC4 Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Marmoset, Tamarin, Horse (100%); Panda, Guinea pig (94%); Mouse, Rat, Elephant, Pig (88%); Bat, Dog, Hamster (82%).
Epitope
N-Terminus
Specificity
Human MC4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (4 - 8 µg/ml)
- ICC (7.5 - 10 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About MC4R / Melanocortin 4 Receptor
Validation
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Prostate, Carcinoma
Prostate, Carcinoma
Anti-MC4 Receptor antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MC4 Receptor antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Breast, carcinoma
Breast, carcinoma
Anti-MC4 Receptor antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with MC4 Receptor.
Anti-MC4 Receptor antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with MC4 Receptor.
Anti-MC4 Receptor antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
Anti-MC4 Receptor antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
See More About...
LSBio Ratings
PathPlus™ MC4R / Melanocortin 4 Receptor Antibody (N-Terminus) for IHC, ICC LS-A1032 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Mouse, Human, Horse
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Species:
Human, Monkey, Rabbit, Sheep
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey, Mouse, Rat, Bovine, Dog, Pig, Rabbit, Sheep
Applications:
IHC, IHC - Paraffin, Western blot
Source:
E. coli
Tag:
His-GST
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
