MYC (c-Myc) is a multifunctional nuclear phosphoprotein that plays a central role in cell cycle progression, apoptosis and cellular transformation. It is one of the Yamanaka master transcription factors (MYC, OCT4/POU5F1, SOX2 and KLF4) that are involved in transdifferentiation, induced pluripotency and aging. It regulates the transcription of thousands of specific target genes (roughly 15% of all genes), and it generally upregulates their expression. MYC itself is broadly overexpressed in cervical, colorectal, breast, lung, stomach and other cancers. Mutations, rearrangements and translocations of this gene have also been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt’s lymphoma. In immunohistochemistry of normal tissues, MYC has nuclear positivity in all cells with the exception of stroma and glial cells. References: Proceedings of the National Academy of Sciences of the United States of America. 85 (9): 3052–6, PMID: 2834731; PLoS One. 2008;3(10):e3534, PMID: 18953412; Science. 2017 Aug 18;357(6352). pii: eaan2507, PMID: 28818916; Cell. 2016 Dec 15;167(7):1719-1733.e12, PMID: 27984723