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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16795-50 | 50 µg (0.76 mg/ml) | $485 |
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PathPlus™ Monoclonal Mouse anti‑Human NGFR / CD271 / TNR16 Antibody (IHC, WB) LS‑B16795
PathPlus™ Monoclonal Mouse anti‑Human NGFR / CD271 / TNR16 Antibody (IHC, WB) LS‑B16795
Note: This antibody replaces LS-C37494
Antibody:
NGFR / CD271 / TNR16 Mouse anti-Human Monoclonal Antibody
Application:
IHC-P, WB, IP, Neut
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
NGFR / CD271 / TNR16 Mouse anti-Human Monoclonal Antibody
Application:
IHC-P, WB, IP, Neut
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Specifications
Description
NGFR (Nerve Growth Factor Receptor, CD271, TNFRSF16) is a member of the TNFR superfamily, and is a low-affinity receptor subunit for nerve growth factor and multiple neurotrophins that stimulate neuron growth and differentiation. NGFR is expressed in peripheral nerves, reticular fibers of germinal centers and the liver, myoepithelial cells, some mesenchymal stromal cells, and glandular epithelium of the prostate and seminal vesicle. It is also a determinant of stem-like properties and tumorigenicity in malignant melanomas. It is expressed in neural crest stem cells and is regarded as a neural crest stem cell marker. It is expressed on the cell membrane.
References: Nature Scientific Reports 2018 8, article 9321; PLoS One https://doi.org/10.1371/journal.pone.0092596; Front med 2017 https://doi.org/10.3389/fmed.2017.00022
Target
Human NGFR / CD271 / TNR16
Synonyms
NGFR | CD271 | CD271 antigen | gp80-LNGFR | Nerve growth factor receptor | p75 ICD | p75(NTR) | p75NTR | TNFR superfamily, member 16 | NGF receptor | TNFRSF16 | p75-NTR
Host
Mouse
Reactivity
Human, Monkey
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Monoclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Immunogen
Human melanoma cell line WM245.
Specificity
Recognizes low affinity p75NTR. Species cross-reactivity: Human, monkey.
Applications
- IHC - Paraffin (10 µg/ml)
- Western blot
- Immunoprecipitation
- Neutralization
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Neutralization. Immunohistochemistry: Reported to detect p75NTR in tissue section. Also used in immuno-electron microscopy. Biological Blockade: Reported to block 125I-labeled NGF binding to its receptor. Western Blot Analysis: 0.1-1 ug/ml of this lot detected p75NTR in RIPA lysates from HS294T cells. Immunoprecipitation: 4 ug of a previous lot immunoprecipitated p75NTR from 500 ug of HS294T RIPA lysate.
Presentation
0.1 M Tris-Glycine, pH 7.4, 0.15 M NaCl, 0.05% Sodium Azide, 30% Glycerol
Storage
Short term: 4°C Long term: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About NGFR / CD271 / TNR16
Validation
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ NGFR / CD271 / TNR16 Antibody for IHC, WB/Western, IP LS-B16795 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Ferret, Rabbit, Feline, Non-Human Primates
Applications:
IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, ICC, Western blot, ELISA
Species:
Rat, Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot, Immunoprecipitation
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/22/2024
Date Requested: 11/22/2024
