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Catalog Number Size Price
LS-A6006-50 50 µg (1 mg/ml) $460 
NR1D1 Antibody - Brain, Alzheimer's, senile plaque
NR1D1 Antibody - Brain, Substantia nigra, pigmented neuron
NR1D1 Antibody - Brain, Glioblastoma
NR1D1 Antibody - Anti-NR1D1 antibody IHC of human brain, thalamus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NR1D1 Antibody - Anti-NR1D1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NR1D1 Antibody - Brain, Alzheimer's, senile plaque
NR1D1 Antibody - Brain, Substantia nigra, pigmented neuron
NR1D1 Antibody - Brain, Glioblastoma
NR1D1 Antibody - Anti-NR1D1 antibody IHC of human brain, thalamus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NR1D1 Antibody - Anti-NR1D1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human NR1D1 Antibody (Internal, IHC) LS‑A6006

PathPlus™ Polyclonal Rabbit anti‑Human NR1D1 Antibody (Internal, IHC) LS‑A6006

Antibody:
NR1D1 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Dog, Rabbit
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-A6006-50

Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
NR1D1 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Dog, Rabbit
Format:
Unconjugated, Unmodified

Specifications

Description
Nuclear receptor subfamily 1, group D, member 1 (NR1D1) is an integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. NR1D1 acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. It regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs). It also represses INSIG2, which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human NR1D1
Synonyms
NR1D1 | EAR1 | Rev-erbA-alpha | Reverba | Reverbaalpha | Rev-erb alpha | Rev-erba | Rev-erbalpha | RevErbAlpha | THRA1 | Rev-ErbAalpha | Ear-1 | HRev | THRAL | V-erbA-related protein 1
Host
Rabbit
Reactivity
Human, Dog, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Monkey, Bat, Horse, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from internal region of human NR1D1. Percent identity with other species by BLAST analysis: Human, Elephant, Panda, Dog, Rabbit (100%); Gorilla, Gibbon, Marmoset, Bat, Horse, Pig (93%); Monkey, Mouse, Bovine (87%); Rat, Hamster (80%).
Epitope
Internal
Specificity
Human NR1D1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About NR1D1
P20393 NM_021724 NP_068370.1

Validation

NR1D1 Antibody - Brain, Alzheimer's, senile plaque
Brain, Alzheimer's, senile plaque
Brain, Alzheimer's, senile plaque

NR1D1 Antibody - Brain, Substantia nigra, pigmented neuron
Brain, Substantia nigra, pigmented neuron
Brain, Substantia nigra, pigmented neuron

NR1D1 Antibody - Brain, Glioblastoma
Brain, Glioblastoma
Brain, Glioblastoma

NR1D1 Antibody - Anti-NR1D1 antibody IHC of human brain, thalamus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR1D1 antibody IHC of human brain, thalamus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR1D1 antibody IHC of human brain, thalamus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

NR1D1 Antibody - Anti-NR1D1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR1D1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR1D1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ NR1D1 Antibody (Internal) for IHC LS-A6006 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 7/19/2024