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| Catalog Number | Size | Price |
|---|---|---|
| LS-A246-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human OXTR / Oxytocin Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A246
PathPlus™ Polyclonal Rabbit anti‑Human OXTR / Oxytocin Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A246
Antibody:
OXTR / Oxytocin Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
OXTR / Oxytocin Receptor Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Oxytocin receptor (OXTR) belongs to the vasopressin/oxytocin family of GPCRs and binds cyclic nonapeptide hormones. The oxytocin receptor functions primarily during labor and lactation. There is a dramatic increase in the number of oxytocin receptors just before the onset of labor causing the uterine muscles to become exceedingly sensitive to oxytocin. OXTR causes an inward membrane current that results in smooth muscle contraction during labor and milk ejection during lactation. OXTR also plays a role in natriuresis, kaliuresis and may have an antistress effect.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human OXTR / Oxytocin Receptor
Synonyms
OXTR | Oxytocin receptor | Oxt-r | OT-R
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human Oxytocin Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%).
Epitope
Cytoplasmic Domain
Specificity
Human Oxytocin Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (10 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About OXTR / Oxytocin Receptor
Validation
Lung, Adenocarcinoma
Lung, Adenocarcinoma
Breast, Lactating
Breast, Lactating
Anti-Oxytocin Receptor antibody IHC of human uterus, term. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Oxytocin Receptor antibody IHC of human uterus, term. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-OXTR / Oxytocin Receptor antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-OXTR / Oxytocin Receptor antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ OXTR / Oxytocin Receptor Antibody (Cytoplasmic Domain) for IHC LS-A246 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (1)
Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. Yoshida M, Takayanagi Y, Inoue K, Kimura T, Young LJ, Onaka T, Nishimori K. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Feb;29:2259-71.
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human, Mouse
Applications:
Western blot, ELISA
Species:
Human, Mouse
Applications:
Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/24/2024
Date Requested: 11/24/2024
