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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16293-100 | 100 µg (200 µg/ml) | $525 |
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human PTH / Parathyroid Hormone Antibody (clone PTH/2295R, IHC) LS‑B16293
PathPlus™ Recombinant Monoclonal Rabbit anti‑Human PTH / Parathyroid Hormone Antibody (clone PTH/2295R, IHC) LS‑B16293
Note: This antibody replaces LS-C751326
Antibody:
PTH / Parathyroid Hormone Rabbit anti-Human Recombinant Monoclonal (PTH/2295R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
PTH / Parathyroid Hormone Rabbit anti-Human Recombinant Monoclonal (PTH/2295R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
Parathyroid hormone (PTH) is a hormone secreted by the parathyroid glands with important functions in the kidney, intestine and bone. These include calcium absorption and regulation, phosphate regulation, bone remodeling, osteoclast activation, and conversion of vitamin D to its active form, calcitriol, in the kidneys. In immunohistochemistry, PTH antibodies may be used to identify parathyroid tissue, where they show strong cytoplasmic staining in chief cells. Staining intensity has been found to decrease in hyperplastic tissue and adenomas when compared to normal parathyroid tissue.
References: Archives of Pathology & Laboratory Medicine. 2010 Nov. 134 (11), 1639-1644, PMID: 21043817; Southern Medical Journal. 2004 May. 97 (5): 506–11, PMID: 15180028; Mol Cell Endocrinol. 2011 Dec 5;347(1-2):25-9, PMID: 21664413; Bone Res. 2016 Oct 18;4:16041, PMID: 27790378; J Endocrinol Invest. 2011 Jul;34(7 Suppl):18-22, PMID: 21985975
Target
Human PTH / Parathyroid Hormone
Synonyms
PTH | Parathyroid hormone | Parathyroid hormone 1 | Parathyrin | Parathormone | PTH1
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Recombinant Monoclonal
Clone
PTH/2295R
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified.
Also available Azide-free, Carrier-free.
Immunogen
Synthetic peptide corresponding to amino acids 1 to 34 of mature PTH conjugated to a carrier. Antigen Molecular Weight: 9 kDa
Specificity
Epitope of this MAb maps in between aa 1-34. PTH is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH) - also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
Applications
- IHC - Paraffin (1:100)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistology (Formalin-fixed - 0.25-0.5 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
About PTH / Parathyroid Hormone
Validation
Human Parathyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Parathyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ PTH / Parathyroid Hormone Antibody (clone PTH/2295R) for IHC LS-B16293 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC - Paraffin, IHC - Frozen
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, IHC - Frozen, ELISA
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Human
Applications:
ICC, Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/22/2024
Date Requested: 12/22/2024
