SCD (stearoyl-CoA desaturase 5, delta-9-desaturase)) represents a terminal component of the liver microsomal stearyl-CoA desaturase system, which utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates, including palmitoyl-CoA and stearoyl-CoA. SCD regulates lipogenesis, cellular proliferation, neuronal differentiation and proliferation in the brain, and plays a role in tumorigenesis. In immunohistochemistry, SCD has cytoplasmic positivity in a majority of tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Biochem. Biophys. Res. Commun. 332:735-742(2005), PMID: 15907797; PLoS One. 2012; 7(6): e39787, PMID: 22745828;