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| Catalog Number | Size | Price |
|---|---|---|
| LS-B6724-50 | 50 µg (0.5 mg/ml) | $485 |
PathPlus™ Monoclonal Mouse anti‑Human SLC1A2 / EAAT2 / GLT‑1 Antibody (C‑Terminus, IHC, WB) LS‑B6724
PathPlus™ Monoclonal Mouse anti‑Human SLC1A2 / EAAT2 / GLT‑1 Antibody (C‑Terminus, IHC, WB) LS‑B6724
Note: This antibody replaces LS-C123622
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Specifications
Description
SLC1A2 (EAAT2, GLT-1) is a member of a family of solute transporter proteins. It is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human SLC1A2 / EAAT2 / GLT-1
Synonyms
SLC1A2 | EAAT-2 | GLT-1 | Glutamate transporter 1 | EAAT2 | GLT1
Host
Mouse
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG1,k
Monoclonal
Purification
Affinity purified
Modifications
Unmodified
Immunogen
Linear peptide corresponding to the C-Terminus of human Excitatory amino acid transporter 2.
Epitope
C-Terminus
Specificity
Recognizes human Excitatory amino acid transporter 2. Species cross-reactivity: mouse. Species sequence homology: rat.
Applications
- IHC
- IHC - Paraffin (10 µg/ml)
- ICC
- Western blot (0.5 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry. Western Blot: 0.5 ug/ml.
Presentation
0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, 0.05% Sodium Azide
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About SLC1A2 / EAAT2 / GLT-1
Validation
Anti-SLC1A2 / EAAT2 antibody IHC of human brain, astrocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-SLC1A2 / EAAT2 antibody IHC of human brain, astrocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
See More About...
LSBio Ratings
PathPlus™ SLC1A2 / EAAT2 / GLT-1 Antibody (C-Terminus) for IHC, ICC, WB/Western LS-B6724 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Species:
Human, Rat
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Rat, Human, Monkey, Mouse, Rabbit
Applications:
IHC
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC - Paraffin, ICC, Flow Cytometry
Species:
Human
Applications:
Western blot, ELISA
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 11/24/2024
Date Requested: 11/24/2024
