Trace amine associated receptor 1 (TAAR1) is a a receptor for biogenic trace amines, which are present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are involved in a variety of physiological and neurological functions, and are implicated in numerous disorders that involve affect and cognition, including depression, ADHD and schizophrenia. The signal transduced by TAAR1 is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804