TIAM1 is a guanine nucleotide exchange factor involved in cell migration and regulation of cell shape. TIAM1 is found in effectively all tumor cell lines, and upregulation of TIAM1 has been suggested to promote proliferation, invasion and metastases in various cancers, including colorectal and renal carcinoma, pancreatic cancer, chondrosarcoma, T-cell lymphoma, and breast cancer. In immunohistochemistry of normal tissue, TIAM1 has cytoplasmic and membranous staining in immune cells and in the cerebellum. References: J Cell Biol. 2000 Jul 10;150(1):177-91, PMID: 10893266, J Biol Chem. 2001 Nov 9;276(45):41889-97, PMID: 11551917; Biorheology. 2003;40(1-3):93-100, PMID: 12454392, PMID: World J Gastroenterol. 2005 Feb 7; 11(5): 705–707, PMID: 15655826, Oncogene. 2010 Dec 16;29(50):6533-42, PMID: 20802514; Mol Cancer Res. 2013 Mar;11(3):230-9; J Cell Biol. 2012 Oct 15;199(2):331-45, PMID: 23071154; J Cell Sci. 2004 Sep 15;117(Pt 20):4863-71, PMID: 15340013