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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16303-100 | 100 µg (0.2 mg/ml) | $525 |
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human TLE1 / TLE 1 Antibody (clone TLE1/2946R, aa 175‑338, IHC) LS‑B16303
PathPlus™ Recombinant Monoclonal Rabbit anti‑Human TLE1 / TLE 1 Antibody (clone TLE1/2946R, aa 175‑338, IHC) LS‑B16303
Note: This antibody replaces LS-C751397
Antibody:
TLE1 / TLE 1 Rabbit anti-Human Recombinant Monoclonal (aa 175-338) (TLE1/2946R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Antibody:
TLE1 / TLE 1 Rabbit anti-Human Recombinant Monoclonal (aa 175-338) (TLE1/2946R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Specifications
Description
TLE1 (transducing-like enhancer of split 1) is a corepressor in the Groucho family of proteins that interacts with DNA-binding transcription factors that have a variety of roles in cell proliferation, development and differentiation. TLE1 has been implicated in neuronal differentiation, pancreatic beta cell development, and has tumor suppressor and oncogenic functions in various cancers. TLE1 is also involved as a negative regulator of inflammation. It is expressed in the nucleus of a variety of tissues.
References: PNAS 2016 113(7):1871; Oncotarget 2017 8(9):1971
Target
Human TLE1 / TLE 1
Synonyms
TLE1 | E(Sp1) homolog | ESG | GRG1 | Enhancer of split groucho 1 | ESG1
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Recombinant Monoclonal
Clone
TLE1/2946R
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified.
Also available Azide-free, Carrier-free.
Immunogen
Recombinant human TLE1 fragment (aa 175-338). Antigen Molecular Weight: 83 kDa
Epitope
aa 175-338
Specificity
Key players in the Notch pathway are the TLE genes, which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. Transducin-like enhancer protein 1 (TLE1) is a protein that is encoded by the TLE1 gene and is involved in control of hematopoiesis, neuronal, and terminal epithelial differentiation. Positive immunohistochemical nuclear staining with anti-TLE-1 has been shown to be a useful addition to an IHC panel when differentiating synovial sarcoma from other soft tissue malignancies.
Applications
- IHC - Paraffin (1:100)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistology (Formalin-fixed - 1-2 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
About TLE1 / TLE 1
Validation
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ TLE1 / TLE 1 Antibody (aa 175-338, clone TLE1/2946R) for IHC LS-B16303 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Mouse, Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen
Species:
Human
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot, Immunoprecipitation
Species:
Mouse
Applications:
IHC - Paraffin, IHC - Frozen
Species:
Human, Mouse, Rat
Applications:
IHC, Immunofluorescence, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 12/21/2024
Date Requested: 12/21/2024
