TRPV1 is a non-selective, calcium permeant cation channel protein that is involved in the detection of thermal stimuli and noxious chemicals following ligand binding. It acts as an endocannabinoid receptor with neuromodulatory effects. TRPV1 is thought to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. It also plays a role in inflammatory pain response, specifically in synaptic transmission in the pain pathway governing pain modulation and exacerbation, and is also involved in hyperalgesia. TRPV1 has membranous positivity on nerve endings in the dorsal root ganglia and throughout the central nervous system and it is also found at low levels in most tissues throughout the body. References: Semin Cell Dev Biol. 2013 Jan;24(1):51-7, PMID: 23000387; Neural Plasticity. 2016. 5954890, DOI: 10.1155/2016/5954890;