ABCA7 is an ATP-binding cassette transporter that carries various molecules across extra- and intra-cellular membranes. This protein has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. ABCA7 is involved in ovarian cancer progression, as it has been found to upregulate the TGF-beta signaling pathway resulting in an accelerated epithelial-to-mesenchymal transition. Knockdown of ABCA7 has been shown to decrease the migration of ovarian cancer cells. In immunohistochemistry of normal tissue, ABCA7 has cytoplasmic and membranous positivity in the brain, bone marrow, lymph nodes, spleen, and thymus, and in leukocytes and immune cells in tissues throughout the body.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Oncol Lett. 2018 Nov;16(5):5868-5874, PMID: 30333865