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PathPlusTM DNMT / DNMT1 Antibodies
DNMT1 is a methyltransferase involved in transcription repression that methylates CpG residues and hemimethylated DNA. It associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand. It also associates with chromatin during the G2 and M phases to maintain DNA methylation independent of replication. It is responsible for maintaining methylation patterns established in development. It is upregulated or dysregulated in some cancers driven by epigenetic deregulation, such as CIMP (CpG Island Methylator Phenotype) colorectal cancers (high expression) and gliomas. In immunohistochemistry of normal tissue, it has nuclear positivity in highly proliferative cells, as well as in fetal tissues, the placenta, heart, kidney, and peripheral blood mononuclear cells, and is found at lower levels in most tissues throughout the body. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Am J Pathol. 2004 Feb; 164(2): 689–699, PMID: 14742272; Oncotarget. 2017 Jan 24; 8(4): 6940–6954, PMID: 28036297

2 PathPlusTM Antibodies
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Antibodies (2)
Primary (2)
DNMT / DNMT1 (2)
Human (2)
Mouse (2)
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mouse (1)
goat (1)
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PathPlus Cancer (2)
IgG1 (1)
monoclonal mc (1)
polyclonal pc (1)
60B1220.1 (1)
Unconjugated (2)
aa637-650 (1)
aa891-904 (1)
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Yes (1)
DNMT / DNMT1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
DNMT / DNMT1 Goat anti-Human Polyclonal (aa891-904) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
DNMT / DNMT1 Antibody - Anti-DNMT1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Cancer
DNMT / DNMT1 Mouse anti-Human Monoclonal (aa637-650) (60B1220.1) Antibody
Rabbit, Mouse, Horse, Bat, Human, Monkey
ChrIP, IHC-P, IP, WB
Unconjugated
50 µg/$440
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