FOXC1 is a forkhead transcription factor involved in embryogenesis, cardiac morphogenesis and ocular development. Inherited mutations in FOXC1 lead to glaucoma, Axenfeld-Rieger syndrome and cerebral small-vessel disease (CSVD), described by increased risk for stroke and progressive cognitive decline. Upregulation of FOXC1 in cancer is common and linked with poor prognosis, as it leads to increased expression of vimentin, N-cadherin and fibronectin and consequently promotes migration and metastasis. In immunohistochemistry, FOXC1 has highest cytoplasmic and nuclear positivity in the central nervous system and salivary gland, and is also moderately expressed in most other tissues throughout the body. References: Developmental biology. 2006. 421-436. ISBN-10: 0-87893-243-7; Molecular Medicine Reports. 12 (6): 8003–9, PMID: 26461269; Oncogene. 2017 Jul 13;36(28):3957-3963, PMID: 28288141; J Clin Invest. 2014 Nov;124(11):4877-81, PMID: 25250569