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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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PathPlusTM NR5A1 / SF1 Antibodies
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.

2 PathPlusTM Antibodies
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NR5A1 / SF1 (2)
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NR5A1 / SF1 Antibody - Anti-NR5A1 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer Pathology
Cancer
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NR5A1 / SF1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
NR5A1 / SF1 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
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NR5A1 / SF1 Rabbit anti-Human Polyclonal (Internal) Antibody
Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
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