S100A4 is a member of the S100 family of calcium-binding proteins that is involved in the regulation of angiogenesis, cell survival, motility and invasion. It is expressed in the nucleus, cytoplasm and extracellular space. It is expressed in a variety of cell types, including fibroblasts, macrophages, lymphocytes, neutrophils, endothelial cells, and smooth muscle. S100A4 also has been implicated in tumor progression and metastasis by stimulating cell motility, stimulating degradation of matrix components and stimulating angiogenesis. References: Oncotarget 2017 8(42):73219; Am J Pathol 2010 176(2):528