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| Catalog Number | Size | Price |
|---|---|---|
| LS-G3795-10 | 10 µg | $330 |
| LS-G3795-50 | 50 µg | $463 |
Human FGF21 Protein (Recombinant Human IgG1 Fc) (aa1-209) - LS-G3795
Human FGF21 Protein (Recombinant Human IgG1 Fc) (aa1-209) - LS-G3795
Description:
FGF21 Protein LS-G3795 is a Recombinant Human FGF21 produced in HEK 293 Cells aa 1-209 with Human IgG1 Fc tag(s). It is low in endotoxin; Less than 0.1 EU/µg protein (determined by LAL method). For Research Use Only
Toll Free North America
(800) 227-6666
(800) 227-6666For Research Use Only
Overview
Description:
FGF21 Protein LS-G3795 is a Recombinant Human FGF21 produced in HEK 293 Cells aa 1-209 with Human IgG1 Fc tag(s). It is low in endotoxin; Less than 0.1 EU/µg protein (determined by LAL method). For Research Use Only
Specifications
Type
Recombinant Protein
Target
FGF21
Synonyms
FGF21 | Fibroblast growth factor 21 | FGF-21
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Tag
Human IgG1 Fc
Region
aa 1-209
Predicted Molecular Weight
~50kDa (SDS-PAGE)
Expression System
HEK 293 Cells
Source Species
Human
Purification
Greater than 95% by SDS-PAGE
Bio-Activity
Activates ERK and FRS2alpha phosphorylation in bKlotho expressing cells.
Endotoxin
Less than 0.1 EU/µg protein (determined by LAL method).
Presentation
PBS
Storage
Store at 4°C for immediate use, or aliquot and store at -20°C for up to 3 months. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About FGF21
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Functional Assay
ERK and FRS2alpha phosphorylation induced by FGF-21 in bKlotho expressing cells. Klotho expressing cells were serum starved for 16 hours and then stimulated with hFGF-21-His (competitor), FGF-21-Fc and FGF-b (positive control) for 10 minutes, respectively. Antibodies against pFRS2alpha, pERK1/2 and total ERK1/2 were used for immunoblotting. Lane 1: 1 ug/ml hFGF21-His (competitor) Lane 2: 2.2 ug/ml hFGF21-Fc (Prod. No. AG-40A-0095) Lane 3: 2.2 ug/ml mCD137-Fc (Prod. No. AG-40A-0025) Lane 4: 100ng/ ul FGF-b Lane 5: control (non-treated)
Functional Assay
ERK and FRS2alpha phosphorylation induced by FGF-21 in bKlotho expressing cells. Klotho expressing cells were serum starved for 16 hours and then stimulated with hFGF-21-His (competitor), FGF-21-Fc and FGF-b (positive control) for 10 minutes, respectively. Antibodies against pFRS2alpha, pERK1/2 and total ERK1/2 were used for immunoblotting. Lane 1: 1 ug/ml hFGF21-His (competitor) Lane 2: 2.2 ug/ml hFGF21-Fc (Prod. No. AG-40A-0095) Lane 3: 2.2 ug/ml mCD137-Fc (Prod. No. AG-40A-0025) Lane 4: 100ng/ ul FGF-b Lane 5: control (non-treated)
Functional Assay
ERK and FRS2alpha phosphorylation induced by FGF-21 in bKlotho expressing cells. Klotho expressing cells were serum starved for 16 hours and then stimulated with hFGF-21-His (competitor), FGF-21-Fc and FGF-b (positive control) for 10 minutes, respectively. Antibodies against pFRS2alpha, pERK1/2 and total ERK1/2 were used for immunoblotting. Lane 1: 1 ug/ml hFGF21-His (competitor) Lane 2: 2.2 ug/ml hFGF21-Fc (Prod. No. AG-40A-0095) Lane 3: 2.2 ug/ml mCD137-Fc (Prod. No. AG-40A-0025) Lane 4: 100ng/ ul FGF-b Lane 5: control (non-treated)
Functional Assay
ERK and FRS2alpha phosphorylation induced by FGF-21 in bKlotho expressing cells. Klotho expressing cells were serum starved for 16 hours and then stimulated with hFGF-21-His (competitor), FGF-21-Fc and FGF-b (positive control) for 10 minutes, respectively. Antibodies against pFRS2alpha, pERK1/2 and total ERK1/2 were used for immunoblotting. Lane 1: 1 ug/ml hFGF21-His (competitor) Lane 2: 2.2 ug/ml hFGF21-Fc (Prod. No. AG-40A-0095) Lane 3: 2.2 ug/ml mCD137-Fc (Prod. No. AG-40A-0025) Lane 4: 100ng/ ul FGF-b Lane 5: control (non-treated)
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 1/15/2025
Date Requested: 1/15/2025
