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ABAT
4-aminobutyrate aminotransferase
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
| Gene Name: | 4-aminobutyrate aminotransferase |
| Synonyms: | ABAT, 4-aminobutyrate transaminase, GABA aminotransferase, L-AIBAT, GABA transaminase, NPD009, GABA transferase, GABA-AT, GABA-T, GABAT |
| Target Sequences: | NM_000663 NP_000654.2 P80404 |
Publications (1)
1
Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice. Shen J, Wang C, Ying J, Xu T, McAlinden A, O'Keefe RJ. JCI insight. 2019 September;4:128568. [Full Text Article]
[PubMed:31534049]
[PMC:PMC6795381]
Related Antibodies: LS-B14889.
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ABAT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
ABAT Rabbit anti-Human Polyclonal (aa290-339) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ABAT Mouse anti-Human Monoclonal (aa29-323) (UMAB178) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
ABAT Mouse anti-Human Monoclonal (aa29-323) (Carrier-free) (UMAB178) Antibody
Human
IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
ABAT Mouse anti-Human Monoclonal (aa29-323) (UMAB179) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
ABAT Mouse anti-Human Monoclonal (aa29-323) (Carrier-free) (UMAB179) Antibody
Human
IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
ABAT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
ABAT Mouse anti-Human Monoclonal (aa29-323) (UMAB180) Antibody
Human
IF, IHC, WB
Unconjugated
100 µl/$493
ABAT Mouse anti-Human Monoclonal (aa29-323) (Carrier-free) (UMAB180) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$539
ABAT Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
ABAT Rabbit anti-Human Polyclonal (aa29-300) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
ABAT Mouse anti-Human Monoclonal (aa29-323) (OTI6C9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABAT Mouse anti-Human Monoclonal (aa29-323) (Carrier-free) (OTI6C9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ABAT Mouse anti-Human Monoclonal (aa29-323) (OTI7H1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABAT Mouse anti-Human Monoclonal (aa29-323) (Carrier-free) (OTI7H1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ABAT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ABAT Mouse anti-Human Monoclonal (aa29-323) (OTI6H1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABAT Mouse anti-Human Monoclonal (aa29-323) (Carrier-free) (OTI6H1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ABAT Mouse anti-Human Monoclonal (aa29-323) (OTI1F10) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABAT Mouse anti-Human Monoclonal (aa29-323) (OTI7C4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABAT Mouse anti-Human Monoclonal (aa29-323) (Carrier-free) (OTI7C4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
ABAT Mouse anti-Human Monoclonal (aa29-323) (OTI3F6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABAT Mouse anti-Human Monoclonal (aa29-323) (OTI7E9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABAT Mouse anti-Human Monoclonal (aa29-323) (OTI3D2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABAT Mouse anti-Human Monoclonal (aa29-323) (Carrier-free) (OTI3D2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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