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ABCA1

ATP-binding cassette, sub-family A (ABC1), member 1

ABCA1 (ATP-binding Cassette, Sub-family A, Member 1), also known as ABC1 (ABC Transporter 1) or CERP (Cholesterol efflux regulatory protein), is a member of the family of ATP-binding cassette (ABC) transporters. It is a cAMP-dependent, sulfonylurea-sensitive traffic ATPase, which is located at the plasma membrane and plays a key role in the cellular lipid removal pathway. ABCA1 supports apolipoprotein A-I (APOA1)-mediated cellular efflux of cholesterol and choline-phospholipids into the blood circulation; therefore, ABCA1 defects result in reduced plasma level of high density lipoproteins (HDL) combined with the tissue deposition of cholesteryl esters. Homozygous mutations in ABCA1 are the cause of Tangier disease, which is characterized by the absence of HDL in plasma, hepatosplenomegaly, peripheral neuropathy, and frequently premature coronary artery disease. Noticeably, heterozygous Tangier disease carriers have an approximately 2-fold reduction in HDL level. More commonly, ABCA1 inherited defects are associated with a milder condition, so-called familial hypoalphalipoproteinemia (FHA). FHA patients, similar to Tangier disease patients, demonstrate a very evident decrease of HDL level; however, they lack clinical manifestations.

Gene Name: ATP-binding cassette, sub-family A (ABC1), member 1
Family/Subfamily: Transporter , ATP-binding cassette - ABCA/ABC1
Synonyms: ABCA1, ABC-1, ABC1, CERP, HDLDT1, Tangier disease, ATP-binding cassette 1, Td, Membrane-bound, TGD
Target Sequences: NM_005502 NP_005493.2 O95477

Publications (145)

1
Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux. Burgess JW, Kiss RS, Zheng H, Zachariah S, Marcel YL. The Journal of biological chemistry. 2002 277:31318-26. (WB; Mouse, Human) [PubMed:12050168]
2
LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. Murthy S, Born E, Mathur SN, Field FJ. Journal of lipid research. 2002 43:1054-64. (WB; Human) [PubMed:12091489]
3
ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity. Feng B, Tabas I. The Journal of biological chemistry. 2002 277:43271-80. (WB; Mouse) [PubMed:12215451]
4
Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. Fukumoto H, Deng A, Irizarry MC, Fitzgerald ML, Rebeck GW. The Journal of biological chemistry. 2002 277:48508-13. (WB; Mouse, Human) [PubMed:12384498]
5
ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells. Reddy ST, Hama S, Ng C, Grijalva V, Navab M, Fogelman AM. Arteriosclerosis, thrombosis, and vascular biology. 2002 22:1877-83. [PubMed:12426219]
6
cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts. Haidar B, Denis M, Krimbou L, Marcil M, Genest J. Journal of lipid research. 2002 43:2087-94. (IP; Human) [PubMed:12454270]
7
A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. Wang N, Chen W, Linsel-Nitschke P, Martinez LO, Agerholm-Larsen B, Silver DL, Tall AR. The Journal of clinical investigation. 2003 111:99-107. (WB, IP; Human) [PubMed:12511593] [PMC:PMC151839]
8
Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux. Escher G, Krozowski Z, Croft KD, Sviridov D. The Journal of biological chemistry. 2003 278:11015-9. (WB; Human, Hamster) [PubMed:12531903]
9
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. Koldamova RP, Lefterov IM, Ikonomovic MD, Skoko J, Lefterov PI, Isanski BA, DeKosky ST, Lazo JS. The Journal of biological chemistry. 2003 278:13244-56. (IHC, WB; Rat) [PubMed:12547833]
10
Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations. Basso F, Freeman L, Knapper CL, Remaley A, Stonik J, Neufeld EB, Tansey T, Amar MJ, Fruchart-Najib J, Duverger N, Santamarina-Fojo S, Brewer HB. Journal of lipid research. 2003 44:296-302. (WB; Mouse) [PubMed:12576511]
11
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. Terasaka N, Hiroshima A, Koieyama T, Ubukata N, Morikawa Y, Nakai D, Inaba T. FEBS letters. 2003 536:11-Jun. (IHC-P; Mouse) [PubMed:12586329]
12
Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion. Sun Y, Yao J, Kim TW, Tall AR. The Journal of biological chemistry. 2003 278:27688-94. (WB; Mouse) [PubMed:12754201]
13
Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells. Le Lay S, Robichon C, Le Liepvre X, Dagher G, Ferre P, Dugail I. Journal of lipid research. 2003 44:1499-507. (WB; Mouse) [PubMed:12754274]
14
Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR. Khovidhunkit W, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. Journal of lipid research. 2003 44:1728-36. (WB; Mouse) [PubMed:12777468]
15
Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. Witting SR, Maiorano JN, Davidson WS. The Journal of biological chemistry. 2003 278:40121-7. (WB; Mouse) [PubMed:12890677]
16
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression. Wagner BL, Valledor AF, Shao G, Daige CL, Bischoff ED, Petrowski M, Jepsen K, Baek SH, Heyman RA, Rosenfeld MG, Schulman IG, Glass CK. Molecular and cellular biology. 2003 23:5780-9. (WB; Mouse) [PubMed:12897148] [PMC:PMC166346]
17
Identification and characterization of rodent ABCA1 in isolated type II pneumocytes. Bortnick AE, Favari E, Tao JQ, Francone OL, Reilly M, Zhang Y, Rothblat GH, Bates SR. American journal of physiology. Lung cellular and molecular physiology. 2003 285:L869-78. (WB; Human) [PubMed:12909583]
18
Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade. Zager RA, Johnson AC, Hanson SY. American journal of physiology. Renal physiology. 2003 285:F1092-9. [PubMed:12952856]
19
Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters. Su YR, Ishiguro H, Major AS, Dove DE, Zhang W, Hasty AH, Babaev VR, Linton MF, Fazio S. Molecular therapy : the journal of the American Society of Gene Therapy. 2003 8:576-83. (WB; Mouse) [PubMed:14529830]
20
Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1). Denis M, Haidar B, Marcil M, Bouvier M, Krimbou L, Genest J. The Journal of biological chemistry. 2004 279:7384-94. (IP; Human) [PubMed:14660648]
21
Visualizing lipid structure and raft domains in living cells with two-photon microscopy. Gaus K, Gratton E, Kable EP, Jones AS, Gelissen I, Kritharides L, Jessup W. Proceedings of the National Academy of Sciences of the United States of America. 2003 100:15554-9. (ICC; Mouse, Human) [PubMed:14673117] [PMC:PMC307606]
22
Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. Haidar B, Denis M, Marcil M, Krimbou L, Genest J. The Journal of biological chemistry. 2004 279:9963-9. (IP; Human) [PubMed:14701824]
23
Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. Gaus K, Kritharides L, Schmitz G, Boettcher A, Drobnik W, Langmann T, Quinn CM, Death A, Dean RT, Jessup W. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2004 18:574-6. [PubMed:14734645]
24
Molecular interactions between apoE and ABCA1: impact on apoE lipidation. Krimbou L, Denis M, Haidar B, Carrier M, Marcil M, Genest J. Journal of lipid research. 2004 45:839-48. (IP; Human) [PubMed:14754908]
25
LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells. Field FJ, Born E, Mathur SN. Journal of lipid research. 2004 45:905-13. (WB; Human) [PubMed:14993242]
26
ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes. Sahoo D, Trischuk TC, Chan T, Drover VA, Ho S, Chimini G, Agellon LB, Agnihotri R, Francis GA, Lehner R. Journal of lipid research. 2004 45:1122-31. (WB; Rat) [PubMed:14993246]
27
Oxysterols trigger ABCA1-mediated basolateral surfactant efflux. Agassandian M, Mathur SN, Zhou J, Field FJ, Mallampalli RK. American journal of respiratory cell and molecular biology. 2004 31:227-33. [PubMed:15039140]
28
Differential expression of cholesterol hydroxylases in Alzheimer's disease. Brown J, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B. The Journal of biological chemistry. 2004 279:34674-81. (WB; Rabbit, Human) [PubMed:15148325]
29
Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles. Denis M, Haidar B, Marcil M, Bouvier M, Krimbou L, Genest J. The Journal of biological chemistry. 2004 279:41529-36. (IP; Human) [PubMed:15280376]
30
Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism. Zeng L, Liao H, Liu Y, Lee TS, Zhu M, Wang X, Stemerman MB, Zhu Y, Shyy JY. The Journal of biological chemistry. 2004 279:48801-7. (WB; Human) [PubMed:15358760]
31
Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. Bared SM, Buechler C, Boettcher A, Dayoub R, Sigruener A, Grandl M, Rudolph C, Dada A, Schmitz G. Molecular biology of the cell. 2004 15:5399-407. [PubMed:15469992] [PMC:PMC532019]
32
Cellular physiology of cholesterol efflux in vascular endothelial cells. O'Connell BJ, Denis M, Genest J. Circulation. 2004 110:2881-8. [PubMed:15492319]
33
ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages. Dove DE, Su YR, Zhang W, Jerome WG, Swift LL, Linton MF, Fazio S. Arteriosclerosis, thrombosis, and vascular biology. 2005 25:128-34. [PubMed:15499044]
34
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease. Koldamova RP, Lefterov IM, Staufenbiel M, Wolfe D, Huang S, Glorioso JC, Walter M, Roth MG, Lazo JS. The Journal of biological chemistry. 2005 280:4079-88. (WB; Mouse) [PubMed:15557325]
35
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass CK. The Journal of clinical investigation. 2004 114:1564-76. [PubMed:15578089] [PMC:PMC529277]
36
Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator. Glaros EN, Kim WS, Quinn CM, Wong J, Gelissen I, Jessup W, Garner B. The Journal of biological chemistry. 2005 280:24515-23. (WB; Human) [PubMed:15890646]
37
Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression. Forcheron F, Legedz L, Chinetti G, Feugier P, Letexier D, Bricca G, Beylot M. Arteriosclerosis, thrombosis, and vascular biology. 2005 25:1711-7. [PubMed:15961705]
38
IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride. Berfield AK, Chait A, Oram JF, Zager RA, Johnson AC, Abrass CK. American journal of physiology. Renal physiology. 2006 290:F138-47. [PubMed:16077083]
39
Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size. Boisvert WA, Rose DM, Boullier A, Quehenberger O, Sydlaske A, Johnson KA, Curtiss LK, Terkeltaub R. Arteriosclerosis, thrombosis, and vascular biology. 2006 26:563-9. [PubMed:16410462]
40
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC. Journal of lipid research. 2006 47:832-43. [PubMed:16418537]
41
TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells. Gerbod-Giannone MC, Li Y, Holleboom A, Han S, Hsu LC, Tabas I, Tall AR. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:3112-7. [PubMed:16492740] [PMC:PMC1413897]
42
Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice. Dong J, Liu J, Lou B, Li Z, Ye X, Wu M, Jiang XC. Journal of lipid research. 2006 47:1307-14. [PubMed:16508036]
43
Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice. Trogan E, Feig JE, Dogan S, Rothblat GH, Angeli V, Tacke F, Randolph GJ, Fisher EA. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:3781-6. [PubMed:16537455] [PMC:PMC1450154]
44
NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs. Zhang C, Yin W, Liao D, Huang L, Tang C, Tsutsumi K, Wang Z, Liu Y, Li Q, Hou H, Cai M, Xiao J. Journal of lipid research. 2006 47:2055-63. (WB; Pig) [PubMed:16807312]
45
ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines. Sporstl M, Mousavi SA, Eskild W, Roos N, Berg T. BMC molecular biology. 2007 8:5. [PubMed:17241464] [PMC:PMC1790708]
46
SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes. Atshaves BP, McIntosh AL, Payne HR, Gallegos AM, Landrock K, Maeda N, Kier AB, Schroeder F. Journal of lipid research. 2007 48:2193-211. [PubMed:17609524]
47
Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells. During A, Harrison EH. Journal of lipid research. 2007 48:2283-94. [PubMed:17644776]
48
Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis. Hassan HH, Denis M, Lee DY, Iatan I, Nyholt D, Ruel I, Krimbou L, Genest J. Journal of lipid research. 2007 48:2428-42. [PubMed:17656736]
49
Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF. Circulation. 2007 116:1404-12. [PubMed:17724261]
50
Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317. Talukdar S, Bhatnagar S, Dridi S, Hillgartner FB. Journal of lipid research. 2007 48:2647-63. [PubMed:17823458]
51
Expression and biological activity of ABCA1 in alveolar epithelial cells. Bates SR, Tao JQ, Yu KJ, Borok Z, Crandall ED, Collins HL, Rothblat GH. American journal of respiratory cell and molecular biology. 2008 38:283-92. [PubMed:17884990] [PMC:PMC2258448]
52
The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis. Hoe HS, Cooper MJ, Burns MP, Lewis PA, van der Brug M, Chakraborty G, Cartagena CM, Pak DT, Cookson MR, Rebeck GW. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:10895-905. [PubMed:17913923]
53
Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1. Out R, Jessup W, Le Goff W, Hoekstra M, Gelissen IC, Zhao Y, Kritharides L, Chimini G, Kuiper J, Chapman MJ, Huby T, Van Berkel TJ, Van Eck M. Circulation research. 2008 102:113-20. [PubMed:17967783]
54
OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. Yan D, Myrnp MI, Wong J, Perttil J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM. The Journal of biological chemistry. 2008 283:332-40. [PubMed:17991739]
55
Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism. Zhou X, He W, Huang Z, Gotto AM, Hajjar DP, Han J. The Journal of biological chemistry. 2008 283:2129-38. [PubMed:18029360]
56
ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. Wang N, Yvan-Charvet L, Ltjohann D, Mulder M, Vanmierlo T, Kim TW, Tall AR. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 22:1073-82. [PubMed:18039927]
57
Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein. Jacobs RL, Lingrell S, Zhao Y, Francis GA, Vance DE. The Journal of biological chemistry. 2008 283:2147-55. [PubMed:18042552]
58
Laminar shear stress regulates liver X receptor in vascular endothelial cells. Zhu M, Fu Y, Hou Y, Wang N, Guan Y, Tang C, Shyy JY, Zhu Y. Arteriosclerosis, thrombosis, and vascular biology. 2008 28:527-33. (WB) [PubMed:18096827]
59
Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis. Watanabe T, Nishio K, Kanome T, Matsuyama TA, Koba S, Sakai T, Sato K, Hongo S, Nose K, Ota H, Kobayashi Y, Katagiri T, Shichiri M, Miyazaki A. Circulation. 2008 117:638-48. [PubMed:18212280]
60
Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake. Montoudis A, Seidman E, Boudreau F, Beaulieu JF, Menard D, Elchebly M, Mailhot G, Sane AT, Lambert M, Delvin E, Levy E. Journal of lipid research. 2008 49:961-72. (WB; Human) [PubMed:18235139]
61
Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR. Henry-Berger J, Mouzat K, Baron S, Bernabeu C, Marceau G, Saru JP, Sapin V, Lobaccaro JM, Caira F. Biology of reproduction. 2008 78:968-75. [PubMed:18276933]
62
Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense. Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, Fessler MB. Journal of immunology (Baltimore, Md. : 1950). 2008 180:3305-12. [PubMed:18292555] [PMC:PMC2430066]
63
Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. Ouimet M, Wang MD, Cadotte N, Ho K, Marcel YL. Arteriosclerosis, thrombosis, and vascular biology. 2008 28:1144-50. (WB) [PubMed:18369155]
64
Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression. Tancevski I, Wehinger A, Demetz E, Eller P, Duwensee K, Huber J, Hochegger K, Schgoer W, Fievet C, Stellaard F, Rudling M, Patsch JR, Ritsch A. Endocrinology. 2008 149:3708-12. [PubMed:18388200] [PMC:PMC2993050]
65
OSBP negatively regulates ABCA1 protein stability. Bowden K, Ridgway ND. The Journal of biological chemistry. 2008 283:18210-7. [PubMed:18450749]
66
Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells. Kumar R, McClain D, Young R, Carlson GA. The Journal of general virology. 2008 89:1525-32. [PubMed:18474570] [PMC:PMC2706533]
67
Role of caveolin-1 in the regulation of lipoprotein metabolism. Frank PG, Pavlides S, Cheung MW, Daumer K, Lisanti MP. American journal of physiology. Cell physiology. 2008 295:C242-8. [PubMed:18508910] [PMC:PMC2493562]
68
A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells. Paul V, Meyer HH, Leidl K, Soumian S, Albrecht C. Journal of lipid research. 2008 49:2259-67. [PubMed:18541924]
69
Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo. Mukhamedova N, Escher G, D'Souza W, Tchoua U, Grant A, Krozowski Z, Bukrinsky M, Sviridov D. Journal of lipid research. 2008 49:2312-22. [PubMed:18622028]
70
Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice. Peng D, Hiipakka RA, Dai Q, Guo J, Reardon CA, Getz GS, Liao S. The Journal of pharmacology and experimental therapeutics. 2008 327:332-42. [PubMed:18723776] [PMC:PMC2574974]
71
Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain. Cartagena CM, Ahmed F, Burns MP, Pajoohesh-Ganji A, Pak DT, Faden AI, Rebeck GW. Journal of neurotrauma. 2008 25:1087-98. [PubMed:18729719] [PMC:PMC2745316]
72
Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity. Nakanishi S, Vikstedt R, Sderlund S, Lee-Rueckert M, Hiukka A, Ehnholm C, Muilu M, Metso J, Naukkarinen J, Palotie L, Kovanen PT, Jauhiainen M, Taskinen MR. Journal of lipid research. 2009 50:183-92. [PubMed:18787236]
73
LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1. Delvecchio CJ, Bilan P, Nair P, Capone JP. American journal of physiology. Lung cellular and molecular physiology. 2008 295:L949-57. [PubMed:18820007]
74
A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase. Robichaud JC, Francis GA, Vance DE. The Journal of biological chemistry. 2008 283:35496-506. [PubMed:18842588]
75
ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity. Nandi S, Ma L, Denis M, Karwatsky J, Li Z, Jiang XC, Zha X. Journal of lipid research. 2009 50:456-66. [PubMed:18941142]
76
Defects in the regulatory clearance mechanisms favor the breakdown of self-tolerance during spontaneous autoimmune orchitis. Pelletier RM, Yoon SR, Akpovi CD, Silvas E, Vitale ML. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 296:R743-62. [PubMed:19052317]
77
Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. Dang H, Liu Y, Pang W, Li C, Wang N, Shyy JY, Zhu Y. The Journal of biological chemistry. 2009 284:6218-26. (WB; Mouse) [PubMed:19119143] [PMC:PMC2649084]
78
Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content. Hans CP, Zerfaoui M, Naura AS, Troxclair D, Strong JP, Matrougui K, Boulares AH. The Journal of pharmacology and experimental therapeutics. 2009 329:150-8. [PubMed:19124646] [PMC:PMC2670599]
79
Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. Bhatnagar S, Damron HA, Hillgartner FB. The Journal of biological chemistry. 2009 284:10023-33. [PubMed:19233843] [PMC:PMC2665057]
80
Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium. Duncan KG, Hosseini K, Bailey KR, Yang H, Lowe RJ, Matthes MT, Kane JP, LaVail MM, Schwartz DM, Duncan JL. The British journal of ophthalmology. 2009 93:1116-20. [PubMed:19304587] [PMC:PMC3541028]
81
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney. Kim HJ, Moradi H, Yuan J, Norris K, Vaziri ND. American journal of physiology. Renal physiology. 2009 296:F1297-306. [PubMed:19357177] [PMC:PMC2692452]
82
CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages. Bujold K, Rhainds D, Jossart C, Febbraio M, Marleau S, Ong H. Cardiovascular research. 2009 83:457-64. [PubMed:19377069]
83
LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner. Ouvrier A, Cadet R, Vernet P, Laillet B, Chardigny JM, Lobaccaro JM, Drevet JR, Saez F. Journal of lipid research. 2009 50:1766-75. [PubMed:19395734] [PMC:PMC2724773]
84
Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling. Ronis MJ, Chen Y, Badeaux J, Badger TM. The Journal of nutrition. 2009 139:1431-8. [PubMed:19515742]
85
Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice. Liu J, Huan C, Chakraborty M, Zhang H, Lu D, Kuo MS, Cao G, Jiang XC. Circulation research. 2009 105:295-303. [PubMed:19590047] [PMC:PMC2746935]
86
Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis. Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T. Circulation research. 2009 105:500-10. [PubMed:19644050]
87
Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2. Welch C, Santra MK, El-Assaad W, Zhu X, Huber WE, Keys RA, Teodoro JG, Green MR. Cancer research. 2009 69:6782-9. [PubMed:19706769] [PMC:PMC2841785]
88
An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2. Maitra U, Parks JS, Li L. Molecular and cellular biology. 2009 29:5989-97. [PubMed:19752193] [PMC:PMC2772564]
89
The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor. Tang C, Liu Y, Kessler PS, Vaughan AM, Oram JF. The Journal of biological chemistry. 2009 284:32336-43. [PubMed:19783654] [PMC:PMC2781648]
90
Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein. Scoles DR, Xu X, Wang H, Tran H, Taylor-Harding B, Li A, Karlan BY. Gynecologic oncology. 2010 116:109-16. (WB; Human) [PubMed:19854496]
91
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. Zhang Y, Yin L, Anderson J, Ma H, Gonzalez FJ, Willson TM, Edwards PA. The Journal of biological chemistry. 2010 285:3035-43. (WB; Mouse, Rat) [PubMed:19996107] [PMC:PMC2823426]
92
High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance. Xue JH, Yuan Z, Wu Y, Liu Y, Zhao Y, Zhang WP, Tian YL, Liu WM, Liu Y, Kishimoto C. Cardiovascular research. 2010 86:141-50. (WB; Human) [PubMed:20007688]
93
Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury. Crisafulli C, Di Paola R, Mazzon E, Paterniti I, Galuppo M, Genovese T, Bramanti P, Cappellani A, Cuzzocrea S. Journal of leukocyte biology. 2010 87:309-21. [PubMed:20028773]
94
The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. McLaren JE, Calder CJ, McSharry BP, Sexton K, Salter RC, Singh NN, Wilkinson GW, Wang EC, Ramji DP. Journal of immunology (Baltimore, Md. : 1950). 2010 184:5827-34. [PubMed:20410491] [PMC:PMC2874519]
95
IL-33 reduces macrophage foam cell formation. McLaren JE, Michael DR, Salter RC, Ashlin TG, Calder CJ, Miller AM, Liew FY, Ramji DP. Journal of immunology (Baltimore, Md. : 1950). 2010 185:1222-9. (WB; Mouse, Human) [PubMed:20543107]
96
Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. Wang F, Okamoto Y, Inoki I, Yoshioka K, Du W, Qi X, Takuwa N, Gonda K, Yamamoto Y, Ohkawa R, Nishiuchi T, Sugimoto N, Yatomi Y, Mitsumori K, Asano M, Kinoshita M, Takuwa Y. The Journal of clinical investigation. 2010 120:3979-95. [PubMed:20978351] [PMC:PMC2964972]
97
Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. Ma L, Dong F, Denis M, Feng Y, Wang MD, Zha X. The Journal of biological chemistry. 2011 286:3370-8. (WB) [PubMed:21106522] [PMC:PMC3030343]
98
Modulation of ABCA1 by an LXR agonist reduces -amyloid levels and improves outcome after traumatic brain injury. Loane DJ, Washington PM, Vardanian L, Pocivavsek A, Hoe HS, Duff KE, Cernak I, Rebeck GW, Faden AI, Burns MP. Journal of neurotrauma. 2011 28:225-36. [PubMed:21175399] [PMC:PMC3037807]
99
Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, Salazar JV, Tontonoz P. Journal of lipid research. 2011 52:531-9. [PubMed:21187453] [PMC:PMC3035689]
100
Modulation of macrophage fatty acid content and composition by exposure to dyslipidemic serum in vitro. Wong BX, Kyle RA, Croft KD, Quinn CM, Jessup W, Yeap BB. Lipids. 2011 46:371-80. [PubMed:21286835]
101
Expression and localization pattern of ABCA1 in diverse human placental primary cells and tissues. Nikitina L, Wenger F, Baumann M, Surbek D, Krner M, Albrecht C. Placenta. 2011 32:420-30. [PubMed:21501868]
102
Critical role of astroglial apolipoprotein E and liver X receptor- expression for microglial A phagocytosis. Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson J, Holtzman DM, Heneka MT. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:7049-59. [PubMed:21562267]
103
Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells. Ting TC, Miyazaki-Anzai S, Masuda M, Levi M, Demer LL, Tintut Y, Miyazaki M. The Journal of biological chemistry. 2011 286:23938-49. [PubMed:21596756] [PMC:PMC3129175]
104
Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects. Chen J, Costa LG, Guizzetti M. The Journal of pharmacology and experimental therapeutics. 2011 338:870-8. [PubMed:21628419] [PMC:PMC3164352]
105
Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. Zhang J, Kris-Etherton PM, Thompson JT, Hannon DB, Gillies PJ, Heuvel JP. The Journal of nutritional biochemistry. 2012 23:400-9. [PubMed:21658928]
106
Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood-brain barrier. Do TM, Ouellet M, Calon F, Chimini G, Chacun H, Farinotti R, Bourasset F. Molecular and cellular biochemistry. 2011 357:397-404. (WB; Mouse) [PubMed:21660464]
107
ABCA1 increases extracellular ATP to mediate cholesterol efflux to ApoA-I. Lee JY, Karwatsky J, Ma L, Zha X. American journal of physiology. Cell physiology. 2011 301:C886-94. [PubMed:21697542]
108
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells. Elali A, Hermann DM. Brain pathology (Zurich, Switzerland). 2012 22:175-87. [PubMed:21767321]
109
Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice. Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim-Kaneyama J, Miyazaki A, Hirano T. Diabetologia. 2011 54:2649-59. (WB; Mouse) [PubMed:21786155] [PMC:PMC3168747]
110
Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis. Iatan I, Bailey D, Ruel I, Hafiane A, Campbell S, Krimbou L, Genest J. Journal of lipid research. 2011 52:2043-55. [PubMed:21846716] [PMC:PMC3196236]
111
Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux. Le Lay S, Rodriguez M, Jessup W, Rentero C, Li Q, Cartland S, Grewal T, Gaus K. PloS one. 2011 6:e23353. [PubMed:21858084] [PMC:PMC3155548]
112
Mycophenolic acid induces ATP-binding cassette transporter A1 (ABCA1) expression through the PPAR-LXR-ABCA1 pathway. Xu Y, Lai F, Xu Y, Wu Y, Liu Q, Li N, Wei Y, Feng T, Zheng Z, Jiang W, Yu L, Hong B, Si S. Biochemical and biophysical research communications. 2011 414:779-82. [PubMed:22005457]
113
Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. Kanter JE, Tang C, Oram JF, Bornfeldt KE. Biochimica et biophysica acta. 2012 1821:358-64. [PubMed:22020260] [PMC:PMC3266440]
114
13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages. Kmmerer I, Ringseis R, Biemann R, Wen G, Eder K. Lipids in health and disease. 2011 10:222. [PubMed:22129452] [PMC:PMC3248880]
115
ABCA1-dependent mobilization of lysosomal cholesterol requires functional Niemann-Pick C2 but not Niemann-Pick C1 protein. Boadu E, Nelson RC, Francis GA. Biochimica et biophysica acta. 2012 1821:396-404. [PubMed:22179027]
116
Loss of liver FA binding protein significantly alters hepatocyte plasma membrane microdomains. McIntosh AL, Atshaves BP, Storey SM, Landrock KK, Landrock D, Martin GG, Kier AB, Schroeder F. Journal of lipid research. 2012 53:467-80. [PubMed:22223861] [PMC:PMC3276470]
117
Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes. Storey SM, McIntosh AL, Huang H, Landrock KK, Martin GG, Landrock D, Payne HR, Atshaves BP, Kier AB, Schroeder F. American journal of physiology. Gastrointestinal and liver physiology. 2012 302:G824-39. (ICC, WB; Mouse) [PubMed:22241858] [PMC:PMC3355564]
118
Lipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-I. Hossain MA, Ngeth S, Chan T, Oda MN, Francis GA. BMC biochemistry. 2012 13:1. [PubMed:22248050] [PMC:PMC3292454]
119
HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux. Cui HL, Grant A, Mukhamedova N, Pushkarsky T, Jennelle L, Dubrovsky L, Gaus K, Fitzgerald ML, Sviridov D, Bukrinsky M. Journal of lipid research. 2012 53:696-708. [PubMed:22262807] [PMC:PMC3307646]
120
Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes. Coleman EM, Walker TN, Hildreth JE. Virology journal. 2012 9:31. [PubMed:22273177] [PMC:PMC3299633]
121
Phospholipase A(2)-modified low-density lipoprotein activates liver X receptor in human macrophages. Morbitzer D, Namgaladze D, Brne B. Cell biochemistry and biophysics. 2012 63:143-9. (WB; Human) [PubMed:22367754]
122
ABCG2- and ABCG4-mediated efflux of amyloid- peptide 1-40 at the mouse blood-brain barrier. Do TM, Noel-Hudson MS, Ribes S, Besengez C, Smirnova M, Cisternino S, Buyse M, Calon F, Chimini G, Chacun H, Scherrmann JM, Farinotti R, Bourasset F. Journal of Alzheimer's disease : JAD. 2012 30:155-66. [PubMed:22391220]
123
Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages. Iio A, Ohguchi K, Iinuma M, Nozawa Y, Ito M. Journal of natural products. 2012 75:563-6. (WB; Human) [PubMed:22429094]
124
ER stress is associated with reduced ABCA-1 protein levels in macrophages treated with advanced glycated albumin - reversal by a chemical chaperone. Castilho G, Okuda LS, Pinto RS, Iborra RT, Nakandakare ER, Santos CX, Laurindo FR, Passarelli M. The international journal of biochemistry & cell biology. 2012 44:1078-86. (ICC; Mouse) [PubMed:22497927]
125
PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXR through the IGF-I-mediated signaling pathway. Tang SL, Chen WJ, Yin K, Zhao GJ, Mo ZC, Lv YC, Ouyang XP, Yu XH, Kuang HJ, Jiang ZS, Fu YC, Tang CK. Atherosclerosis. 2012 222:344-54. (WB; Human) [PubMed:22503545]
126
Mitochondrial DNA polymorphisms specifically modify cerebral -amyloid proteostasis. Scheffler K, Krohn M, Dunkelmann T, Stenzel J, Miroux B, Ibrahim S, von Bohlen Und Halbach O, Heinze HJ, Walker LC, Gsponer JA, Pahnke J. Acta neuropathologica. 2012 124:199-208. (WB; Mouse) [PubMed:22526016]
127
Host HDL biogenesis machinery is recruited to the inclusion of Chlamydia trachomatis-infected cells and regulates chlamydial growth. Cox JV, Naher N, Abdelrahman YM, Belland RJ. Cellular microbiology. 2012 14:1497-512. (ICC; Human) [PubMed:22672264] [PMC:PMC3443303]
128
Effect of 6-O--maltosyl- cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. Okada Y, Ueyama K, Nishikawa J, Semma M, Ichikawa A. Carbohydrate research. 2012 357:68-74. (WB; Mouse) [PubMed:22677519]
129
Efficacy of a therapeutic vaccine using mutated -amyloid sensitized dendritic cells in Alzheimer's mice. Luo Z, Li J, Nabar NR, Lin X, Bai G, Cai J, Zhou SF, Cao C, Wang J. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2012 7:640-55. (IHC; Human) [PubMed:22684353]
130
Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2. Noghero A, Perino A, Seano G, Saglio E, Lo Sasso G, Veglio F, Primo L, Hirsch E, Bussolino F, Morello F. Arteriosclerosis, thrombosis, and vascular biology. 2012 32:2280-8. (ICC; Human) [PubMed:22723445]
131
Liver X receptor and peroxisome proliferator-activated receptor regulate cholesterol transport in murine cholangiocytes. Xia X, Jung D, Webb P, Zhang A, Zhang B, Li L, Ayers SD, Gabbi C, Ueno Y, Gustafsson J, Alpini G, Moore DD, Lesage GD. Hepatology (Baltimore, Md.). 2012 56:2288-96. (ICC, WB; Rat) [PubMed:22729460] [PMC:PMC3469731]
132
miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity. Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA, Baldn A. EMBO molecular medicine. 2012 4:882-95. (WB; Human) [PubMed:22767443] [PMC:PMC3491822]
133
Omega-6 polyunsaturated fatty acids prevent atherosclerosis development in LDLr-KO mice, in spite of displaying a pro-inflammatory profile similar to trans fatty acids. Machado RM, Nakandakare ER, Quintao EC, Cazita PM, Koike MK, Nunes VS, Ferreira FD, Afonso MS, Bombo RP, Machado-Lima A, Soriano FG, Catanozi S, Lottenberg AM. Atherosclerosis. 2012 224:66-74. (ICC, IHC, IHC-Fr; Mouse) [PubMed:22809447]
134
Mechanisms underlying the rapid peroxisome proliferator-activated receptor--mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. Mandrekar-Colucci S, Karlo JC, Landreth GE. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:10117-28. (WB; Mouse) [PubMed:22836247] [PMC:PMC3433721]
135
Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver. Kurano M, Hara M, Tsuneyama K, Okamoto K, Iso-O N, Matsushima T, Koike K, Tsukamoto K. Journal of lipid research. 2012 53:2275-85. [PubMed:22891292] [PMC:PMC3465997]
136
Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1. Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K. Autoimmunity. 2012 45:568-73. (WB; Human) [PubMed:22913458]
137
Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis. Chen J, Zhang X, Kusumo H, Costa LG, Guizzetti M. Biochimica et biophysica acta. 2013 1831:263-75. (WB; Rat) [PubMed:23010475] [PMC:PMC3534809]
138
Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis. Zhou Q, Mei Y, Shoji T, Han X, Kaminski K, Oh GT, Ongusaha PP, Zhang K, Schmitt H, Moser M, Bode C, Liao JK. Circulation. 2012 126:2236-47. (WB; Mouse) [PubMed:23011471]
139
Advanced glycated albumin isolated from poorly controlled type 1 diabetes mellitus patients alters macrophage gene expression impairing ABCA-1-mediated reverse cholesterol transport. Machado-Lima A, Iborra RT, Pinto RS, Sartori CH, Oliveira ER, Nakandakare ER, Stefano JT, Giannella-Neto D, Corra-Giannella ML, Passarelli M. Diabetes/metabolism research and reviews. 2013 29:66-76. (ICC; Human) [PubMed:23015358]
140
Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype. Cardilo-Reis L, Gruber S, Schreier SM, Drechsler M, Papac-Milicevic N, Weber C, Wagner O, Stangl H, Soehnlein O, Binder CJ. EMBO molecular medicine. 2012 4:1072-86. (IHC, WB; Mouse) [PubMed:23027612] [PMC:PMC3491837]
141
Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin. Maitra U, Li L. Arteriosclerosis, thrombosis, and vascular biology. 2013 33:24-33. (WB; Mouse) [PubMed:23117655] [PMC:PMC3545450]
142
Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia. Dominguez JA, Xie Y, Dunne WM, Yoseph BP, Burd EM, Coopersmith CM, Davidson NO. PloS one. 2012 7:e49159. (WB; Mouse) [PubMed:23145105] [PMC:PMC3493497]
143
TLR2 stimulates ABCA1 expression via PKC- and PLD2 pathway. Park DW, Lee HK, Lyu JH, Chin H, Kang SW, Kim YJ, Bae YS, Baek SH. Biochemical and biophysical research communications. 2013 430:933-7. (WB; Mouse) [PubMed:23261454]
144
Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C signaling in THP-1 macrophage-derived foam cells. Liu XY, Lu Q, Ouyang XP, Tang SL, Zhao GJ, Lv YC, He PP, Kuang HJ, Tang YY, Fu Y, Zhang DW, Tang CK. Atherosclerosis. 2013 226:398-407. (WB; Human) [PubMed:23290264]
145
Knock-down of the oxysterol receptor LXR impairs cholesterol efflux in human primary macrophages: Lack of compensation by LXR activation. Ma S, Yu H, Zhao Z, Luo Z, Chen J, Ni Y, Jin R, Ma L, Wang P, Zhu Z, Li L, Zhong J, Liu D, Nilius B, Zhu Z. Biochemical pharmacology. 2013 (WB; Human) [PubMed:23313547]
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ABCA1 Antibody - Anti-ABCA1 antibody IHC of human colon, ganglion cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PathPlus™ ABCA1 Antibody (aa1100-1300) LS-B3038
Neuroscience
(5.0) Rating
ABCA1 Rabbit anti-Human Polyclonal (aa1100-1300) Antibody
Chicken, Mouse, Dog, Rat, Hamster, Pig, Mustelid, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
ABCA1 Antibody - Anti-ABCA1 antibody IHC of human colon, ganglion cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCA1 Antibody (Biotin) LS-C83838
ABCA1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Chicken, Mouse, Dog, Rat, Hamster, Pig, Mustelid, Human
Flo, ICC, IF, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
ABCA1 Antibody - Anti-ABCA1 antibody IHC of human colon, ganglion cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCA1 Antibody (DY488) LS-C142145
ABCA1 Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Rat, Human
Flo, ICC, IF, IHC, IHC-P, IP, WB
DY488 Conjugated
0.1 ml/$416
ABCA1 Antibody - Anti-ABCA1 antibody IHC of human colon, ganglion cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCA1 Antibody (DY650) LS-C142144
ABCA1 Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Rat, Human
Flo, ICC, IF, IHC, IHC-P, IP, WB
DY650 Conjugated
0.1 ml/$416
ABCA1 Antibody - Anti-ABCA1 antibody IHC of human colon, ganglion cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ABCA1 Antibody (DY550) LS-C142146
ABCA1 Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Rat, Human
Flo, ICC, IF, IHC, IHC-P, IP, WB
DY550 Conjugated
0.1 ml/$416
ABCA1 ELISA Kit
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Human ABCA1 (Sandwich ELISA) ELISA Kit - LS-F20946
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ABCA1 ELISA Kit
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Mouse ABCA1 (Sandwich ELISA) ELISA Kit - LS-F33723
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
ABCA1 Protein - Recombinant ATP Binding Cassette Transporter A1 By SDS-PAGE
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Human ABCA1 Protein (Recombinant His-T7) (aa1385-1663) - LS-G13540
E. coli
His-T7
34.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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ABCA1 Antibody (N-Terminus) LS-C63373
ABCA1 Mouse anti-Mouse Monoclonal (N-Terminus) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µl/$634
ABCA1 Antibody - Immunohistochemistry of ABCA7 in human spleen tissue with ABCA7 antibody at 5µg/ml.
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ABCA1 Antibody LS-C153710
ABCA1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, WB
Unconjugated
0.1 mg/$460
ABCA1 ELISA Kit
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Human ABCA1 (Sandwich ELISA) ELISA Kit - LS-F4501
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
ABCA1 Antibody - Anti-ABCA1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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PathPlus™ ABCA1 Antibody (aa100-150) LS-B7326
Neuroscience
(5.0) Rating
ABCA1 Rabbit anti-Human Polyclonal (aa100-150) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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ABCA1 Antibody (HRP) LS-C543262
ABCA1 Mouse anti-Human Monoclonal (HRP) Antibody
Chicken, Mouse, Human
IHC, IP, Peptide-ELISA, WB
HRP Conjugated
100 µl/$1,119
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ABCA1 Antibody (Biotin) LS-C523129
ABCA1 Mouse anti-Human Monoclonal (Biotin) Antibody
Chicken, Mouse, Human
ELISA, IHC, IP, WB
Biotin Conjugated
100 µl/$1,119
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ABCA1 Antibody (FITC) LS-C533173
ABCA1 Mouse anti-Human Monoclonal (FITC) Antibody
Chicken, Mouse, Human
ELISA, IHC, IP, WB
FITC Conjugated
100 µl/$1,119
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ABCA1 Antibody (APC) LS-C514913
ABCA1 Mouse anti-Human Monoclonal (APC) Antibody
Chicken, Mouse, Human
ELISA, IHC, IP, WB
APC Conjugated
100 µl/$1,119
Select
ABCA1 Antibody (PE) LS-C651374
ABCA1 Mouse anti-Human Monoclonal (PE) Antibody
Chicken, Mouse, Human
ELISA, IHC, IP, WB
PE Conjugated
100 µl/$1,119
ABCA1 Antibody
Select
ABCA1 Antibody LS-C137303
ABCA1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$332
Select
ABCA1 Antibody (N-Terminus) LS-C63367
ABCA1 Mouse anti-Mouse Monoclonal (N-Terminus) Antibody
Mouse, Rat
WB
Unconjugated
100 µg/$649
ABCA1 Antibody - Immunofluorescence analysis of C6 cells using ABCA1 Polyclonal Antibody at dilution of 1:100 (40x lens).Blue: DAPI for nuclear staining.
Select
ABCA1 Antibody LS-C833720
ABCA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
ABCA1 Antibody - Western blot of recombinant ABCA1.
Select
ABCA1 Antibody (aa1385-1663) LS-C314724
ABCA1 Rabbit anti-Human Polyclonal (aa1385-1663) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
Select
ABCA1 Antibody LS-C126509
ABCA1 Rat anti-Mouse Monoclonal Antibody
Mouse
Flo, IF, WB
Unconjugated
50 µg/$384; 100 µg/$499; 250 µg/$763
Select
ABCA1 Antibody (Biotin) LS-C523128
ABCA1 Rat anti-Mouse Monoclonal (Biotin) Antibody
Mouse
Flo, IF, WB
Biotin Conjugated
100 µl/$973
Select
ABCA1 Antibody (aa1800-2260, clone AB.H10) LS-C136791
ABCA1 Mouse anti-Human Monoclonal (aa1800-2260) (AB.H10) Antibody
Chicken, Mouse, Human
IHC, IP, Peptide-ELISA, WB
Unconjugated
100 µg/$346
ABCA1 Protein - Recombinant ATP Binding Cassette Transporter A1 By SDS-PAGE
Select
Mouse ABCA1 Protein (Recombinant His) (aa1404-1663) - LS-G13539
E. coli
His
30.1 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
Viewing 1-25 of 75 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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