ABCB2 / TAP1

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

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Proteins (3)

Type

Recombinant (3)

Target

ABCB2 / TAP1 (3)

Publications

No (3)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Species

Human (3)

Source

E. coli (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human ABCB2 / TAP1 Protein (Recombinant GST) (Full Length) - LS-G30621

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

113.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ABCB2 / TAP1 Protein (Recombinant GST, N-terminus) (aa241-350) - LS-G60281

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ABCB2 / TAP1 Protein (Recombinant His-T7) (aa525-808) - LS-G25221

Source:

E. coli

Tag:

His-T7

Molecular Weight:

34.6 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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