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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
Gene Name: | ATP-binding cassette, sub-family B (MDR/TAP), member 6 |
Family/Subfamily: | Transporter , ATP-binding cassette - ABCB/MDR |
Synonyms: | ABCB6, ABC14, ABC, EST45597, LAN, MTABC3, PrP, P-glycoprotein-related protein, MCOPCB7, Mt-ABC transporter 3, Umat |
Target Sequences: | AJ289233 AAH00559.1 Q9NP58 |
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