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ABCC11 / MRP8
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E217betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.
| Gene Name: | ATP-binding cassette, sub-family C (CFTR/MRP), member 11 |
| Family/Subfamily: | Transporter , ATP-binding cassette - ABCC/MRP |
| Synonyms: | ABCC11, EWWD, Multi-resistance protein 8, MRP8, WW |
| Target Sequences: | NM_032583 NP_115972.2 Q96J66 |
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