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ABCC2 / MRP2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

ABCC2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Family/Subfamily: Transporter , ATP-binding cassette - ABCC/MRP
Synonyms: ABCC2, ABC30, CMOAT1, CMOAT, DJS, Multidrug resistance protein 2, MRP2, CMRP
Target Sequences: NM_000392 NP_000383.1 Q92887

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Proteins (2)
Recombinant (2)
ABCC2 / MRP2 (2)
No (2)
GST, N-terminus (1)
His (1)
Human (2)
E. coli (1)
Wheat Germ Extract (1)
ABCC2 / MRP2 Protein - Recombinant ATP Binding Cassette Transporter C2 By SDS-PAGE
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E. coli
His
29.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
ABCC2 / MRP2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).